MAB5280X

Sigma-Aldrich

Anti-Tyrosine Hydroxylase Antibody, clone 2/40/15, Alexa Fluor® 488

clone 2/40/15, Chemicon®, from mouse

eCl@ss:
32160702
NACRES:
NA.41

品質水準

100

由来生物

mouse

antibody product type

primary antibodies

クローン

2/40/15, monoclonal

species reactivity

rat, bovine, quail, chicken

manufacturer/tradename

Chemicon®

アプリケーション

immunohistochemistry: suitable

アイソタイプ

IgG2a

結合体

ALEXA FLUOR® 488

NCBIアクセッション番号

UniProtアクセッション番号

出荷済み

wet ice

特異性

Tyrosine hydroxylase (TH) catalyzes the rate-determining initial step in the biosynthesis of catecholamines such as dopamine, noradrenaline and adrenaline. Therefore the antibody is used to stain dopaminergeous and adrenergeous neurons as well as the chromaffine tissue of the adrenal medulla. Cell lines such as the PC 12 line, which is derived from a rat pheochromocytoma also, show positive reactions. In immunoblots of adrenal medulla tissue, the antibody recognizes a single protein band in the molecular weight range of 56 - 60 kD.

免疫原

Purified tyrosine hydroxylase (EC 1.14.16.2) from a rat pheochromocytoma (2).

アプリケーション

Research Sub Category
神経伝達物質及び受容体

神経細胞及びグリアマーカー
Research Category
ニューロサイエンス
Immunohistochemistry

Optimal working dilutions must be determined by end user.
Anti-Tyrosine Hydroxylase Antibody, clone 2/40/15, Alexa Fluor 488 is an antibody against Tyrosine Hydroxylase for use in IH.

物理的形状

Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in Phosphate buffer with 15 mg/mL BSA as a stabilizer and 0.1% sodium azide.

保管および安定性

Maintain at 2-8°C in undiluted aliquots in the dark for up to 6 months after date of receipt.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

ALEXA FLUOR is a registered trademark of Life Technologies
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

ドイツ水質汚染分類

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

試験成績書(COA)
原産地証明書(COO)
Selective and persistent activation of extracellular signal-regulated protein kinase by nitric oxide in glial cells induces neuronal degeneration in glutathione-depleted midbrain cultures.
Canals, Santiago, et al.
Molecular and Cellular Neurosciences, 24, 1012-1026 (2003)
Jonathan Wills et al.
PloS one, 6(3), e17953-e17953 (2011-03-30)
Tauopathic pathways lead to degenerative changes in Alzheimer's disease and there is evidence that they are also involved in the neurodegenerative pathology of Parkinson's disease [PD]. We have examined tauopathic changes in striatum of the α-synuclein (α-Syn) A53T mutant mouse....
Thomas Haggerty et al.
The European journal of neuroscience, 33(9), 1598-1610 (2011-04-02)
Although clinically distinct diseases, tauopathies and synucleinopathies share a common genesis and mechanisms, leading to overlapping degenerative changes within neurons. In human postmortem striatum of Parkinson's disease (PD) and PD with dementia, we have recently described elevated levels of tauopathy...
Genevieve M Kruger et al.
Neuron, 35(4), 657-669 (2002-08-27)
We found neural crest stem cells (NCSCs) in the adult gut. Postnatal gut NCSCs were isolated by flow-cytometry and compared to fetal gut NCSCs. They self-renewed extensively in culture but less than fetal gut NCSCs. Postnatal gut NCSCs made neurons...

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