Needed to be recrystallized - MS showed contamination with Na.
S9876
スルファチアゾール
Sulfathiazole
別名:
4-アミノ-N-(2-チアゾリル)ベンゼンスルホンアミド, N1-(2-チアゾリル)スルファニルアミド
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この商品について
実験式（ヒル表記法）:
C9H9N3O2S2
CAS番号:
分子量:
255.32
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-771-5
Beilstein/REAXYS Number:
226178
MDL number:
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InChI key
JNMRHUJNCSQMMB-UHFFFAOYSA-N
InChI
1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2nccs2
grade
analytical standard
agency
EPA 1694
form
powder
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
200-202 °C (lit.)
application(s)
clinical testing
Quality Level
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当該品目 | 46902 | 1636504 | S2158000 |
|---|---|---|---|
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - |
| application(s) clinical testing | application(s) clinical testing | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) |
| form powder | form - | form - | form - |
| Quality Level 100 | Quality Level 200 | Quality Level - | Quality Level - |
| grade analytical standard | grade analytical standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard |
| agency EPA 1694 | agency EPA 1694 | agency - | agency - |
Application
Sulfathiazole is used as an analytical reference standard for the quantification of the analyte in meat,[1][2] and honey[3] samples using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Biochem/physiol Actions
スルホンアミド系抗生物質で、ジヒドロプテロイン酸シンタ-ゼを阻害することにより、ジヒドロ葉酸の合成を阻害します。
作用機序:原核生物における葉酸合成を阻害します。
抗菌スペクトル:グラム陽性菌、グラム陰性菌、クラミジア
耐性機序:ジヒドロプテロイン酸シンタ-ゼの変異または別の葉酸合成経路の利用。
作用機序:原核生物における葉酸合成を阻害します。
抗菌スペクトル:グラム陽性菌、グラム陰性菌、クラミジア
耐性機序:ジヒドロプテロイン酸シンタ-ゼの変異または別の葉酸合成経路の利用。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves
Quantitative LC/MS-MS determination of sulfonamides and some other antibiotics in honey
Kaufmann A, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 85(4), 853-860 (2002)
Comparison of separation conditions and ionization methods for the liquid chromatography?mass spectrometric determination of sulfonamides
Kim H-D and Lee WD
Journal of Chromatography A, 984(1), 153-158 (2003)
Determination of sulfonamides in meat by liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry
Kim H-D, et al.
Bull. Korean Chem. Soc., 23(11), 1590-1594 (2002)
T Lotti et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 66(7), 1519-1526 (2012-08-07)
The feasibility of anaerobic ammonium oxidation (anammox) process to treat wastewaters containing antibiotics and heavy metals (such as the liquid fraction of the anaerobically digested swine manure) was studied in this work. The specific anammox activity (SAA) was evaluated by
Mi-Kyung Yun et al.
Science (New York, N.Y.), 335(6072), 1110-1114 (2012-03-03)
The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have severely compromised the usefulness of these drugs. We report structural, computational, and mutagenesis studies on the catalytic
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