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Merck

B1760

ベンゾ[a]ピレン

≥96% (HPLC)

別名:

3,4-ベンズピレン, 3,4-ベンゾピレン, ベンゾ[def]クリセン

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サイズを選択してください

100 MG

¥15,500

500 MG

¥46,800

1 G

¥83,900

5 G

¥317,000

¥15,500


本日発送予定詳細


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この商品について

実験式(ヒル表記法):
C20H12
CAS番号:
分子量:
252.31
UNSPSC Code:
12352005
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-028-5
Beilstein/REAXYS Number:
1911333
MDL number:

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製品名

ベンゾ[a]ピレン, ≥96% (HPLC)

InChI key

FMMWHPNWAFZXNH-UHFFFAOYSA-N

InChI

1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H

SMILES string

c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45

assay

≥96% (HPLC)

form

solid

bp

495 °C (lit.)

mp

177-180 °C (lit.)

Quality Level

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当該品目
ERMAC0515196848564
ベンゾ[a]ピレン ERM®, certified reference material

ERMAC051

ベンゾ[a]ピレン

assay

≥96% (HPLC)

assay

-

assay

-

assay

-

form

solid

form

-

form

-

form

-

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

100

bp

495 °C (lit.)

bp

495 °C (lit.)

bp

495 °C (lit.)

bp

495 °C (lit.)

mp

177-180 °C (lit.)

mp

177-180 °C (lit.)

mp

177-180 °C (lit.)

mp

177-180 °C (lit.)

Application

多環芳香族炭化水素汚染物質であるベンゾ[a]ピレン(PAH)は、癌の実験的モデルで化学発癌性物質として使用されています。発癌性は、CYP1A1によるPAHのベンゾ[a]ピレンジオールエポキシドへの酸化で決まり、この酸化産物はDNAと共に脱プリン化付加物を生成し、これが解離して脱塩基損傷を形成します。ベンゾ[a]ピレンは、アリルヒドロカーボン受容体(AhR)のリガンドで、CYP1A1の誘導などのその生物学的作用の一部は、AhRの活性化に媒介されると思われます。

Related product

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - Repr. 1B - Skin Sens. 1

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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試験成績書(COA)

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Yi-Chen Lin et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-08-17)
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon formed by the incomplete combustion of organic matter. Environmental B[a]P contamination poses a serious health risk to many organisms because the pollutant may negatively affect many physiological systems. As such, chronic exposure to
Audrey Barranger et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-11)
This study aimed to assess the ecotoxicological effects of the interaction of fullerene (C60) and benzo[a]pyrene (B[a]P) on the marine mussel, Mytilus galloprovincialis. The uptake of nC60, B[a]P and mixtures of nC60 and B[a]P into tissues was confirmed by Gas
Ariel Revel et al.
Journal of applied toxicology : JAT, 23(4), 255-261 (2003-07-29)
Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts. Because BaP metabolization requires cytochrome
Yuji Fujita et al.
Bioorganic & medicinal chemistry, 18(3), 1194-1203 (2010-01-12)
The physiological role of aryl hydrocarbon receptor (AhR) is not yet fully understood, and investigation is hampered by the limited solubility of reported AhR ligands in aqueous media. To achieve improved solubility, we focused on our previous finding that planarity-disruption
Xin-Chun Zhao et al.
EBioMedicine, 53, 102689-102689 (2020-03-03)
How the oncoprotein epidermal growth factor receptor (EGFR) evades proteolytic degradation and accumulates in non-small cell lung cancer (NSCLC) remains unclear, and ubiquitin pathway genes (UPGs) that are critical to NSCLC needs to be systematically identified. A total of 696

資料

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

質問

1–2/2 質問  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      役に立ちましたか?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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