SAB6012080

Anti GNE Antibody, clone 23GB5560, Rabbit Monoclonal

clone 23GB5560, recombinant rabbit monoclonal, expressed in HEK293 cells

• 別名: DMRV, GLCNE, IBM2, UAE1
• UNSPSCコード: 12352203

特性

• 由来生物: rabbit (Monoclonal)
• 品質水準: 100
• リコンビナント: expressed in HEK 293 cells
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: 23GB5560, recombinant monoclonal
• フォーム: buffered aqueous glycerol solution
• 分子量: 79 kDa
• 交差性: human
• 包装: vial of 1.5 mL
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• sustainability: Greener Alternative Product
• 濃度: 0.6 mg/ml
• テクニック: western blot: 1:1,000-1:5,000
• アイソタイプ: IgG
• Ensembl |ヒトアクセッション番号: ENSG00000159921
• NCBIアクセッション番号: NP_005467.1
• UniProtアクセッション番号: Q9Y223
• 環境により配慮した代替製品カテゴリ: DfS-Developed
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GNE(10020)

詳細

詳細

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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免疫原

A synthesized peptide corresponding to a sequence within amino acids 701-722 of human GNE [NP_005467.1].

物理的形状

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

その他情報

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.