G1918

Gö 6983

Name: Gö 6983
Brand: SIGMA
Price: 3534 MXP

≥97%, PKC inhibitor, powder

Sinónimos:

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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500 μG

MXP 3,534.00

1 MG

MXP 4,831.00

MXP 3,534.00

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Fórmula empírica (notación de Hill):

C₂₆H₂₆N₄O₃

Número CAS:

133053-19-7

Peso molecular:

442.51

UNSPSC Code:

12352200

PubChem Substance ID:

24894916

NACRES:

NA.77

MDL number:

MFCD04040031

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Nombre del producto

Gö 6983, ≥97%

SMILES string

COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChI key

LLJJDLHGZUOMQP-UHFFFAOYSA-N

assay

≥97%

form

powder

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Categorías relacionadas

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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Este artículo	SML1679	SML1225	SML0412
Sigma-Aldrich G1918 Gö 6983	Sigma-Aldrich SML1679 DEL-22379	Sigma-Aldrich SML1225 Indisulam	Sigma-Aldrich SML0412 IM-54
form powder	form powder	form powder	form powder
assay ≥97%	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL, clear	solubility DMSO: 10 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 5 mg/mL (clear solution)

Application

GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import.[1] It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).[2]

Biochem/physiol Actions

Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC₅₀ = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC₅₀ = 20 mM).

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

Shahbazi MN, et al.

Nature, 552(7684), 239-239 (2017)

Derivation of novel human ground state naive pluripotent stem cells.

Ohad Gafni et al.

Nature, 504(7479), 282-286 (2013-11-01)

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

Li-Chun Lisa Tsai et al.

The Journal of biological chemistry, 290(36), 21845-21856 (2015-07-19)

Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibitory peptide (ZIP)

Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect.

Shirley E Bradley et al.

The Journal of biological chemistry, 285(7), 4883-4895 (2009-11-18)

Expression of the VACM-1/cul5 gene in endothelial and in cancer cell lines in vitro inhibits cellular proliferation and decreases phosphorylation of MAPK. Structure-function analysis of the VACM-1 protein sequence identified consensus sites specific for phosphorylation by protein kinases A and

Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance.

Debasree Dutta et al.

Stem cells (Dayton, Ohio), 29(4), 618-628 (2011-02-11)

The intricate molecular mechanisms that regulate ESC pluripotency are incompletely understood. Prior research indicated that activation of the Janus kinase-signal transducer and activator of transcription (STAT3) pathway or inhibition of extracellular signal-regulated kinase/glycogen synthase kinase 3 (ERK/GSK3) signaling maintains mouse

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Naive Pluripotent Stem Cell Culture in Serum-Free Media

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

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Gö 6983