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Merck
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Documentos

G1918

Sigma-Aldrich

Gö 6983

≥97%

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Todas las fotos(2)
Sinónimos:
3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Fórmula empírica (notación de Hill):
C26H26N4O3
Número de CAS:
133053-19-7
Peso molecular:
442.51
Número MDL:
MFCD04040031
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24894916
NACRES:
NA.77

Nivel de calidad

100

Análisis

≥97%

formulario

powder

solubilidad

DMSO: 10 mg/mL, clear

temp. de almacenamiento

−20°C

cadena SMILES

COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

Clave InChI

LLJJDLHGZUOMQP-UHFFFAOYSA-N

Aplicación

GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).

Acciones bioquímicas o fisiológicas

Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Ohad Gafni et al.
Nature, 504(7479), 282-286 (2013-11-01)
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
Shahbazi MN, et al.
Nature, 552(7684), 239-239 (2017)
Li-Chun Lisa Tsai et al.
The Journal of biological chemistry, 290(36), 21845-21856 (2015-07-19)
Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibitory peptide (ZIP)
Shirley E Bradley et al.
The Journal of biological chemistry, 285(7), 4883-4895 (2009-11-18)
Expression of the VACM-1/cul5 gene in endothelial and in cancer cell lines in vitro inhibits cellular proliferation and decreases phosphorylation of MAPK. Structure-function analysis of the VACM-1 protein sequence identified consensus sites specific for phosphorylation by protein kinases A and
Hila Asraf et al.
iScience, 25(2), 103751-103751 (2022-02-05)
Modulation of the neuronal K+/Cl- cotransporter 2 (KCC2) activity, which mediates Cl- export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an essential component of membrane insertion machinery. Using
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