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8.08260
Trifluoroacetic acid
for synthesis
Synonym(s):
TFA
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About This Item
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Product Name
Trifluoroacetic acid, for synthesis
InChI
1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
SMILES string
OC(C(F)(F)F)=O
InChI key
DTQVDTLACAAQTR-UHFFFAOYSA-N
grade
synthesis grade
vapor density
3.9 (vs air)
vapor pressure
97.5 mmHg ( 20 °C)
assay
≥99% (acidimetric)
form
liquid
dilution
(for synthesis)
refractive index
n20/D 1.3 (lit.)
pH
1 (10 g/L in H2O)
bp
72.4 °C (lit.)
mp
−15.4 °C (lit.)
solubility
soluble 10 g/mL
density
1.489 g/mL at 20 °C (lit.)
storage temp.
2-30°C
Quality Level
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Related Categories
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This Item | T6508 | 299537 | 80457 |
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| assay ≥99% (acidimetric) | assay 99% | assay ≥99% | assay ≥99.0% (GC) |
| solubility soluble 10 g/mL | solubility ethanol: soluble 0.33 mL/mL | solubility - | solubility - |
| form liquid | form liquid | form liquid | form liquid |
| density 1.489 g/mL at 20 °C (lit.) | density 1.489 g/mL at 20 °C (lit.) | density 1.489 g/mL at 20 °C (lit.) | density 1.489 g/mL at 20 °C (lit.) |
| vapor density 3.9 (vs air) | vapor density 3.9 (vs air) | vapor density 3.9 (vs air) | vapor density 3.9 (vs air) |
Analysis Note
Density (d 20 °C/ 4 °C): 1.487 - 1.490
Identity (IR): passes test
Application
- In the direct conversion of cyclohexanone to caprolactam using acetonitrile as the additive.
- In the synthesis of 1,2,4,5-tetrasubstituted imidazoles by four-component condensation of benzil, aldehydes, amines, and ammonium acetate.
- In the synthesis of d-α-Tterpineo from d-limonene by Markovnikov addition followed by hydrolysis.
Features and Benefits
- High acidity
- Easy elimination
- Good solubility in organic solvent and in water.
General description
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 2
flash_point_f
>212.0 °F - Pensky-Martens closed cup
flash_point_c
> 100 °C - Pensky-Martens closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Protocols
Fmoc resin cleavage and deprotection are crucial steps for peptide synthesis, yielding the desired peptide after resin detachment.
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Does the packaging for this item include an airtight septum to prevent exposure to the atmosphere and to allow product to be removed from the bottle with a syringe?
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This product has no septum. The packaging includes a DN 32 screw cap.
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