SRP5091

TGFβR1 (80-end), active, GST tagged human

Name: TGFβR1 (80-end), active, GST tagged human
Brand: SIGMA

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

AAT5, ACVRLK4, ALK-5, LDS1A, LSD2A, SKR4, TGFR-1

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About This Item

UNSPSC Code:

12352200

NACRES:

NA.32

Key Documents

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recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO^® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

2.5-3.5 nmol/min·mg

mol wt

~66 kDa

NCBI accession no.

BC071181

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TGFBR1(7046)

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This Item	SRP5145	T0203	SRP5020
Sigma-Aldrich SRP5091 TGFβR1 (80-end), active, GST tagged human	Sigma-Aldrich SRP5145 TGFβR1 (80-end), GST tagged human	Sigma-Aldrich T0203 TGFβR2 (190-end), active, GST tagged human	Sigma-Aldrich SRP5020 DDR1 (444-end), active, GST tagged human
assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells
mol wt ~66 kDa	mol wt ~65 kDa	mol wt ~68 kDa	mol wt ~77 kDa
form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
storage temp. −70°C	storage temp. −70°C	storage temp. −70°C	storage temp. −70°C

General description

TGFβR1 or transforming growth factor, beta-receptor 1 is a member of the TGFβ receptor subfamily and is a ser/thr protein kinase that forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Mutations in TGFβR1gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFβR1-dependent signaling is required for angiogenesis but not for the development of hematopoietic progenitor cells and functional hematopoiesis.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

N270-2

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TGFBR1 and TGFBR2 mutations in patients with features of Marfan syndrome and Loeys-Dietz syndrome.

Krishna Kumar Singh et al.

Human mutation, 27(8), 770-777 (2006-06-27)

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder characterized by manifestations in the cardiovascular, skeletal, ocular, and other organ systems. MFS type1 (MFS1) is caused by mutations in the gene encoding fibrillin (FBN1). Recently, the transforming growth factor-beta

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice.

J Larsson et al.

The EMBO journal, 20(7), 1663-1673 (2001-04-04)

Deletion of the transforming growth factor beta1 (TGF-beta1) gene in mice has previously suggested that it regulates both hematopoiesis and angiogenesis. To define the function of TGF-beta more precisely, we inactivated the TGF-beta type I receptor (TbetaRI) gene by gene

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TGFβR1 (80-end), active, GST tagged human