T0203

TGFβR2 (190-end), active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(s): AAT3, FAA3, HPNCC6, MFS2, RIIC, TAAD2, TGFR-2
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• Quality Level: 100
• recombinant: expressed in baculovirus infected Sf9 cells
• product line: PRECISIO^® Kinase
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 6-8 nmol/min·mg
• mol wt: ~68 kDa
• UniProt accession no.: P37173
• application(s): cell analysis
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... TGFBR2(7048)

Description

General description

Transforming growth factor β receptor 2 (TGFBR2) is a member of the TGFß receptor subfamily and is a serine/threonine protein kinase. The gene encoding this protein is localized on human chromosome 3p24.1.[1][2]

Biochem/physiol Actions

Transforming growth factor β receptor 2 (TGFBR2)-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses.[3] The TGFBR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-β type II receptor. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome and the development of various types of tumors.[4][5][6][7]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)