P1600000

Physostigmine salicylate

European Pharmacopoeia (EP) Reference Standard

• Synonym(s): Eserine salicylate salt, Physostigmine salicylate salt
• Empirical Formula (Hill Notation): C₁₅H₂₁N₃O₂ · C₇H₆O₃
• CAS Number: 57-64-7
• Molecular Weight: 413.47
• Beilstein/REAXYS Number: 3900576
• MDL number: MFCD00135659
• UNSPSC Code: 41116107
• PubChem Substance ID: 329820099
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: physostigmine
• manufacturer/tradename: EDQM
• mp: 181-183 °C
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: OC(=O)c1ccccc1O.CNC(=O)Oc2ccc3N(C)[C@H]4N(C)CC[C@@]4(C)c3c2
• InChI: 1S/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/m1./s1
• InChI key: HZOTZTANVBDFOF-PBCQUBLHSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Physostigmine salicylate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H330
• pcodes: P301 + P310 + P330 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable