05-682

Anti-Mps1 Antibody, NT, clone 3-472-1

Name: Anti-Mps1 Antibody, NT, clone 3-472-1
Brand: MM
Price: 490 USD

clone 3-472-1, Upstate^®, from mouse

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200 μG

$490.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Key Documents

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Product Name

Anti-Mps1 Antibody, NT, clone 3-472-1, clone 3-472-1, Upstate^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

3-472-1, monoclonal

species reactivity

human

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_003318

UniProt accession no.

P33981

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... C5AR2(27202)

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This Item	05-683	MAB1563	MABS1171
Sigma-Aldrich 05-682 Anti-Mps1 Antibody, NT, clone 3-472-1	Sigma-Aldrich 05-683 Anti-Mps1 Antibody, CT, clone 4-112-3	Sigma-Aldrich MAB1563 Anti-Presenilin-1 Antibody, NT, clone hPS1-NT	Sigma-Aldrich MABS1171 Anti-MPST Antibody, clone 1H10.1
antibody form purified antibody	antibody form purified immunoglobulin	antibody form culture supernatant	antibody form purified immunoglobulin
biological source mouse	biological source mouse	biological source rat	biological source mouse
species reactivity human	species reactivity human	species reactivity human	species reactivity human
clone 3-472-1, monoclonal	clone 4-112-3, monoclonal	clone hPS1-NT, monoclonal	clone 1H10.1, monoclonal
UniProt accession no. P33981	UniProt accession no. P33981	UniProt accession no. P49768	UniProt accession no. P25325
technique(s) western blot: suitable	technique(s) immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable	technique(s) ELISA: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunohistochemistry: suitable (paraffin), western blot: suitable

Analysis Note

routinely evaluated by immunoblot on HeLa total cell extract

Application

Detect Mps1 with Anti-Mps1 Antibody, NT, clone 3-472-1 (Mouse Monoclonal Antibody), that has been shown to work in WB.

General description

97kDa

Mps1 was previously known as TTK/PYK

Physical form

Format: Purified

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis.

Mandar R Bhonde et al.

The Journal of biological chemistry, 281(13), 8675-8685 (2006-02-01)

DNA damage induced by the topoisomerase I inhibitor irinotecan (CPT-11) triggers in p53(WT) colorectal carcinoma cells a long term cell cycle arrest and in p53MUT cells a transient arrest followed by apoptosis (Magrini, R., Bhonde, M. R., Hanski, M. L.

Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning.

Christopher P Mattison et al.

Cell cycle (Georgetown, Tex.), 10(5), 783-793 (2011-02-18)

The Mps1 family of protein kinases contributes to cell cycle control by regulating multiple microtubule cytoskeleton activities. We have uncovered a new Mps1 substrate that provides a novel link between Mps1 and the actin cytoskeleton. We have identified a conserved

PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance.

Elodie Montaudon et al.

Nature communications, 11(1), 4053-4053 (2020-08-15)

A significant proportion of patients with oestrogen receptor (ER) positive breast cancers (BC) develop resistance to endocrine treatments (ET) and relapse with metastatic disease. Here we perform whole exome sequencing and gene expression analysis of matched primary breast tumours and

Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint.

Ballister, ER; Riegman, M; Lampson, MA

The Journal of cell biology null

ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.

Pingzhao Zhang et al.

Oncotarget, 6(39), 41550-41565 (2015-11-26)

Regulated interactions between kinetochores and spindle microtubules are critical for maintaining genomic stability during chromosome segregation. Defects in chromosome segregation are widespread phenomenon in human cancers that are thought to serve as the fuel for tumorigenic progression. Tumor suppressor proteins

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