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MilliporeSigma

14-515

MAP Kinase 1/Erk1 Protein, inactive, 50 g

Unactive, N-terminal GST-tagged, recombinant, full-length, human MAP Kinase 1/Erk1, for use in Kinase Assays.

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50 μG

$635.00

$635.00


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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
eCl@ss:
32160405

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Product Name

MAP Kinase 1/Erk1 Protein, inactive, 50 g, Unactive, N-terminal GST-tagged, recombinant, full-length, human MAP Kinase 1/Erk1, for use in Kinase Assays.

biological source

human

recombinant

expressed in E. coli

mol wt

Mw 70 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Quality Level

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This Item
14-53614-19814-439-M
biological source

human

biological source

human

biological source

mouse

biological source

human

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

UniProt accession no.

P28482

UniProt accession no.

P28482

UniProt accession no.

P63085

UniProt accession no.

P28482

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

-

mol wt

Mw 70 kDa

mol wt

Mw 67.8 kDa

mol wt

Mw 67.8 kDa

mol wt

Mw 69.9 kDa

Analysis Note

routinely evaluated by phosphorylation of MBP substrate in vitro

Application

Research Category
Metabolism
Research Sub Category
Obesity

Metabolic Disorders

Biochem/physiol Actions

Protein Target: MAPK1
Target Sub-Family: CMGC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

N-terminal GST-tagged, recombinant, full-length, human MAP Kinase 1/Erk1
Product Source: expressed in E. coli

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Glutathione-agarose

Preparation Note

6 months at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 2


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ivana Yen et al.
Cancer cell, 34(4), 611-625 (2018-10-10)
Targeting KRAS mutant tumors through inhibition of individual downstream pathways has had limited clinical success. Here we report that RAF inhibitors exhibit little efficacy in KRAS mutant tumors. In combination drug screens, MEK and PI3K inhibitors synergized with pan-RAF inhibitors

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