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164606

Aminopeptidase N/CD13 Inhibitor

The Aminopeptidase N/CD13 Inhibitor controls the biological activity of Aminopeptidase N/CD13. This small molecule/inhibitor is primarily used for Neuroscience applications.

Synonym(s):

Aminopeptidase N/CD13 Inhibitor, 4-tert-butylphenyl hydrogen 1-aminopropylphosphonate

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10 MG

$175.00

$175.00


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About This Item

Empirical Formula (Hill Notation):
C13H22NO3P
Molecular Weight:
271.29
UNSPSC Code:
12352200
NACRES:
NA.77

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Quality Level

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

0.1 M NaOH: 1 mg/mL
DMSO: 1 mg/mL (Only partially soluble)
water: 1 mg/mL (only partially soluble)

shipped in

wet ice

storage temp.

−20°C

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This Item
528111444252217531
assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

0.1 M NaOH: 1 mg/mL, water: 1 mg/mL (only partially soluble), DMSO: 1 mg/mL (Only partially soluble)

solubility

DMSO: 10 mg/mL

solubility

methanol: 1 mg/mL, DMSO: 100 mg/mL

solubility

DMSO: 50 mg/mL

General description

An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC50=1.1 µM). Cell growth is dose dependently inhibited by as much as ~36% and ~60% in PANC-1 and HT-1080 cells, respectively when 300 µM of compound 4d is co-treated with 30 µg/ml of TNF. When treated with compound 4d alone, cell growth is dose-dependently inhibited by as much as 26% and 36%, in the same cell lines, respectively.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Grzywa, R., et al. 2010. Bioorg. Med. Chem.8, 2930.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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