164610

p-Aminophenylmercuric Acetate

≥90% (HPLC), MMP activator, solid

• Synonym(s): p-Aminophenylmercuric Acetate, APMA
• Empirical Formula (Hill Notation): C₈H₉HgNO₂
• CAS Number: 6283-24-5
• Molecular Weight: 351.75
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00007820

Properties

• Product Name: p-Aminophenylmercuric Acetate, An organomercurial agent used for the activation of latent MMPs in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch.
• SMILES string: [Hg+]c1ccc(cc1)N.[O-]C(=O)C
• InChI: 1S/C6H6N.C2H4O2.Hg/c7-6-4-2-1-3-5-6;1-2(3)4;/h2-5H,7H2;1H3,(H,3,4);/q;;+1/p-1
• InChI key: RXSUFCOOZSGWSW-UHFFFAOYSA-M
• description: RTECS - OV5550000
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: yellow
• solubility: 0.1 M NaOH: 10 mg/mL; DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• Quality Level: 100

Description

Other Notes

Chen, J.-M., et al. 1991. J. Biol. Chem. 266, 5113.
Marcy, A.I., et al. 1991. Biochemistry30, 6476.
Stricklin, G.P., et al. 1983. Biochemistry22, 61.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activation of latent MMPs in vitro

Product does not compete with ATP.

Reversible: no

Disclaimer

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Toxicity: Highly Toxic (H)

General description

An organomercurial agent used for the activation of latent matrix metalloproteinases (MMPs) in vitro. Acts by facilitating the loss of the enzyme propeptide domain through an autolytic cleavage known as the cysteine switch.

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H300 + H310 + H330,H373,H410
• pcodes: P262 - P264 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable