Apolipoprotein B, Human Plasma, Low-Density Lipoprotein

Name: Apolipoprotein B, Human Plasma, Low-Density Lipoprotein
Brand: MM

Native apolipoprotein B from human plasma. It is a dominant protein constituent of LDL and VLDL. Acts as a ligand for LDL receptor, directing clearance of LDL from plasma to the liver.

Synonym(s):

Apo B, Apo B-100

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.25

Key Documents

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Quality Level

100

assay

≥95% (SDS-PAGE)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

shipped in

ambient

storage temp.

−20°C

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This Item	ALP30	178468	178461
Sigma-Aldrich 178456 Apolipoprotein B, Human Plasma, Low-Density Lipoprotein	Sigma-Aldrich ALP30 Apolipoprotein B, human	Sigma-Aldrich 178468 Apolipoprotein E, Human Plasma, Very Low-Density Lipoprotein	Sigma-Aldrich 178461 Apolipoprotein C-III, Human Plasma, Very Low-Density Lipoprotein
assay ≥95% (SDS-PAGE)	assay >95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
form solid	form solid	form liquid	form liquid
shipped in ambient	shipped in dry ice	shipped in wet ice	shipped in wet ice
storage condition OK to freeze	storage condition -	storage condition OK to freeze, avoid repeated freeze/thaw cycles	storage condition OK to freeze, avoid repeated freeze/thaw cycles
storage temp. −20°C	storage temp. -	storage temp. −20°C	storage temp. −20°C
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100

General description

Native apolipoprotein B from human plasma. Produced by the liver, and is a dominant protein constituent of LDL that is also present in VLDL. Ligand for LDL receptor, directing clearance of LDL from plasma to the liver. Functions as a cofactor in enzymatic reactions. Mean serum concentration: 950 µg/ml. Higher levels are reported in familial hyperlipidemia, obesity, and diabetes.

Physical form

Lyophilized from 50 mM Na₂CO₃, 50 mM NaCl, 10 mM sodium deoxycholate, pH 10.0.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Please refer to the label for lot-specific reconstitution volume.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Jiang, X.C., et al. 2001. Nat. Med.1, 847.
Zhou, M., et al. 1995. J. Biol. Chem.270, 25220.
Sivaram, P., et al. 1993. J. Biol. Chem.269, 9409.
Sato, R., et al. 1990. J. Biol. Chem. 265, 11880.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An apolipoprotein B100 mimotope prevents obesity in mice.

Hyo Joon Kim et al.

Clinical science (London, England : 1979), 130(2), 105-116 (2015-11-01)

Although apolipoprotein B100 (ApoB100) plays a key role in peripheral fat deposition, it is not considered a suitable therapeutic target in obesity. In the present study we describe a novel ApoB100 mimotope, peptide pB1, and the use of pB1-based vaccine-like

Transferrin coated nanoparticles: study of the bionano interface in human plasma.

Andrzej S Pitek et al.

PloS one, 7(7), e40685-e40685 (2012-07-26)

It is now well established that the surface of nanoparticles (NPs) in a biological environment is immediately modified by the adsorption of biomolecules with the formation of a protein corona and it is also accepted that the protein corona, rather

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