MAB4162

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17

Name: Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17
Brand: MM
Price: 575 USD

clone MM4.17, Chemicon^®, from mouse

Synonym(s):

P-glycoprotein, CD243, p170, Pgp

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100 μG

$575.00

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Key Documents

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biological source

mouse

Quality Level

300

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MM4.17, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable

isotype

IgG2aκ

NCBI accession no.

NM_000927.3

UniProt accession no.

P08183

shipped in

wet ice

Related Categories

Flow Cytometry Antibodies

Protein Biology

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Show Differences

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This Item	MAB4163	MAB4334Z	MAB4120
Sigma-Aldrich MAB4162 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17	Sigma-Aldrich MAB4163 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57	Sigma-Aldrich MAB4334Z Anti-MDR1 Antibody, clone UIC2, azide free	Sigma-Aldrich MAB4120 Anti-MDR1 Antibody, clone JSB-1
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity human	species reactivity human	species reactivity primate, human	species reactivity human, hamster
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form culture supernatant
clone MM4.17, monoclonal	clone MC57, monoclonal	clone UIC2, monoclonal	clone JSB-1, monoclonal
technique(s) flow cytometry: suitable, immunohistochemistry: suitable	technique(s) flow cytometry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable	technique(s) flow cytometry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable	technique(s) flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable (paraffin), western blot: suitable
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice

Application

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 is an antibody against MDR1 for use in FC, IH.

Flow Cytometry

Immunohistochemistry on formalin fixed paraffin embedded sections

Confocal and Electron Microscopy

ELISA

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Recognizes a mapped epitope in the extracellular Pgp domain and detects low-level Pgp expression in living (intact) human MDR cells (Cianfriglia, 2002). The epitope has been mapped to the single amino acid level using different techniques (Cianfriglia, 1994 and Poloni, 1995).

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.

Paola Turella et al.

The Journal of biological chemistry, 281(33), 23725-23732 (2006-06-14)

The new glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines, i.e. CEM-VBL10, CEM-VBL100, and U-2 OS/DX580. The mechanism of cell death triggered by NBDHEX has been deeply investigated in leukemia cell lines. Kinetic data indicate a

Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells.

Jingwei Zhang et al.

British journal of pharmacology, 165(1), 120-134 (2011-05-28)

Intracellular pharmacokinetics of anticancer drugs in multi-drug resistance (MDR) cancer cells is hugely important in the evaluation and improvement of drug efficacy. By using adriamycin as a probe drug in MDR cancer cells, we developed a cellular pharmacokinetic-pharmacodynamic (PK-PD) model

Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer.

Masahiro Yasunaga et al.

Scientific reports, 4, 4852-4852 (2014-05-02)

The treatment of colorectal cancer (CRC) might be improved by the identification of a signalling pathway that could be targeted with novel therapeutics. The results of this study indicate that the taurine transporter SLC6A6 is highly expressed in CRC cells

Melanoma chemotherapy leads to the selection of ABCB5-expressing cells.

Marine Chartrain et al.

PloS one, 7(5), e36762-e36762 (2012-06-08)

Metastatic melanoma is the most aggressive skin cancer. Recently, phenotypically distinct subpopulations of tumor cells were identified. Among them, ABCB5-expressing cells were proposed to display an enhanced tumorigenicity with stem cell-like properties. In addition, ABCB5(+) cells are thought to participate

Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer.

Wanyuan Chen et al.

Oncology reports, 41(1), 67-76 (2018-10-27)

Pancreatic cancer (PC) is a lethal solid malignancy with resistance to traditional chemotherapy. Recently, considerable studies have demonstrated the ubiquitous antitumor properties of gene therapy mediated by the oncolytic vaccinia virus. The second mitochondrial‑derived activator of caspase (Smac) has been

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