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Mettler-Toledo Calibration substance ME 18872, Caffeine

analytical standard, for the calibration of the thermosystem 900, traceable to primary standards (LGC)

Caffeine, 1,3,7-Trimethylxanthine
Empirical Formula (Hill Notation):
CAS Number:
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EC Number:
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analytical standard

Quality Level


traceable to primary standards (LGC)

shelf life

limited shelf life, expiry date on the certificate and label


234-236.5 °C (lit.)


cleaning products
food and beverages
personal care



SMILES string




InChI key


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General description

Caffeine Mettler-Toledo melting point standard is useful for the routine calibration of Mettler-Toledo melting point instrument. The value for its melting point equals an average of 6 to 12 measurements with a Mettler-Toledo MP70 excellence melting point instrument that is calibrated with primary standards.


Mettler-Toledo calibration standard ME 18872, caffeine (234-236.5 °C) finds its use in the calibration of thermosystem 900, in both pharmacopeia and thermodynamic modes of operation.
This mp standard is also employed as a temperature calibration standard in thermal analysis techniques.

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Features and Benefits

  • Melting point calibration standard traceable to a primary standard from LGC, London
  • Melting points measured in both thermodynamic and pharmacopeia modes
  • Available with certificates of analysis and safety data sheet
  • A product of analytical standard grade that meets the QC/QA requirements of melting point analysis
  • Ready-to-use melting point standard, supplied as a finely ground powder


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Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Are the Mettler-Toledo Calibration melting standards already dried and pulverized, ready to use out of the bottle?

    The answer is yes. All melting point standards are ground to a fine powder, tested as melting point standards and ready to use.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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