91388

Supelco

Hexanoyl-L-carnitine

analytical standard

Synonym(s):
n-Hexanoyl-L-carnitine, (R)-Caproylcarnitine, C6-Carnitine, (2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxohexyl)oxy-1-propanaminium inner salt
Empirical Formula (Hill Notation):
C13H25NO4
CAS Number:
Molecular Weight:
259.34
NACRES:
NB.21
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

assay

≥97.0% (TLC)

optical activity

α/D -21.0±2.0°, c = 0.1 in H2O

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

impurities

≤10% water

format

neat

storage temp.

2-8°C

SMILES string

CN+(C)(C)CC@H(OC(CCCCC)=O)CC(O-)=O

InChI

1S/C13H25NO4/c1-5-6-7-8-13(17)18-11(9-12(15)16)10-14(2,3)4/h11H,5-10H2,1-4H3/t11-/m1/s1

InChI key

VVPRQWTYSNDTEA-LLVKDONJSA-N

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General description

Hexanoyl-L-carnitine belongs to the class of straight-chain acylcarnitines, which are important biomarkers in the diagnosis of carnitine deficiency.

Application

Hexanoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in dried blood spots using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Hexanoyl-L-carnitine may also be used as an analytical standard for the separation and identification of underivatized hexanoyl-L-carnitine in human plasma samples using HPLC-MS/MS.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid
Okamura N, et al.
Pharmaceutical Research, 23(8), 1729-1735 (2006)
Matrix effect?corrected liquid chromatography/tandem mass-spectrometric method for determining acylcarnitines in human urine
Abe K, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 468, 187-194 (2017)
Ralph Fingerhut et al.
Analytical chemistry, 81(9), 3571-3575 (2009-03-28)
Electrospray ionization-tandem mass spectrometry (ESI-MS/MS) is increasingly used in newborn screening programs. Acylcarnitine profiles from dried blood spots (DBS) are used to detect fatty acid oxidation disorders, carnitine cycle disorders, and organic acidurias. Stored dried blood is also a valuable...
Minzhi Peng et al.
Journal of chromatography. A, 1319, 97-106 (2013-10-31)
A simple HPLC-MS/MS method has been established to separate and identify underivatized acylcarnitine isomers. Human plasma samples were deproteinized and concentrated. Acylcarnitines were separated on a reverse phase column and detected with triple quadrupole linear ion trap mass spectrometry. Deuterium-labeled...

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