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Y0000106

Pilocarpine nitrate for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Pilocarpine nitrate salt

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20 MG

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About This Item

Empirical Formula (Hill Notation):
C11H16N2O2 · HNO3
CAS Number:
148-72-1
Molecular Weight:
271.27
Beilstein/REAXYS Number:
4171406
MDL number:
MFCD00078497
UNSPSC Code:
41116107
PubChem Substance ID:
329830847
NACRES:
NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

pilocarpine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

InChI key

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Gene Information

human ... CHRM1(1128), CHRM3(1131)

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1 of 4

This Item
P1700000BP503PHR1494
Pilocarpine nitrate for system suitability European Pharmacopoeia (EP) Reference Standard

Y0000106

Pilocarpine nitrate for system suitability

Pilocarpine nitrate European Pharmacopoeia (EP) Reference Standard

P1700000

Pilocarpine nitrate

Pilocarpine nitrate British Pharmacopoeia (BP) Reference Standard

BP503

Pilocarpine nitrate

Pilocarpine Nitrate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1494

Pilocarpine Nitrate

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

pilocarpine

API family

pilocarpine

API family

pilocarpine

API family

pilocarpine

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Pilocarpine nitrate for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Nonselective muscarinic acetylcholine receptor agonist.
Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

Flame over circleSkull and crossbones
GHS03,GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Storage Class

5.1B - Oxidizing hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
Manuela Mazzuferi et al.
Annals of neurology, 74(4), 560-568 (2013-05-21)
Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies are unlikely to provide both anticonvulsant and disease-modifying effects. A selection of epilepsy-related gene expression data sets were retrieved
Mi-Hyeon Jang et al.
Cell stem cell, 12(2), 215-223 (2013-02-12)
Adult neurogenesis, the process of generating mature neurons from adult neural stem cells, proceeds concurrently with ongoing neuronal circuit activity and is modulated by various physiological and pathological stimuli. The niche mechanism underlying the activity-dependent regulation of the sequential steps
Zechun Peng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(36), 14392-14405 (2013-09-06)
Axonal sprouting of excitatory neurons is frequently observed in temporal lobe epilepsy, but the extent to which inhibitory interneurons undergo similar axonal reorganization remains unclear. The goal of this study was to determine whether somatostatin (SOM)-expressing neurons in stratum (s.)
Olav B Smeland et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1090-1097 (2013-04-25)
Although certain metabolic characteristics such as interictal glucose hypometabolism are well established for temporal lobe epilepsy (TLE), its pathogenesis still remains unclear. Here, we performed a comprehensive study of brain metabolism in a mouse model of TLE, induced by pilocarpine-status
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