43794

1,4-Dithioerythritol

≥99.0% (RT), BioUltra

• Synonym(s): erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE
• Linear Formula: HSCH₂CH(OH)CH(OH)CH₂SH
• CAS Number: 6892-68-8
• Molecular Weight: 154.25
• Beilstein/REAXYS Number: 1719756
• EC Number: 229-998-8
• MDL number: MFCD00063750
• UNSPSC Code: 12161504
• PubChem Substance ID: 57650194
• NACRES: NA.25

Properties

• product line: BioUltra
• assay: ≥99.0% (RT)
• form: powder
• reaction suitability: reagent type: reductant
• impurities: insoluble matter, passes filter test; ≤0.5% 4,5-dihydroxy-1,2-dithiane
• pH: 4.0-6.0 (25 °C, 0.1 M in H₂O)
• mp: 82-84 °C (lit.); 82-85 °C
• solubility: H₂O: 0.1 M at 20 °C, clear, colorless
• anion traces: sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Al: ≤5 mg/kg; As: ≤0.5 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 0.1 M in H₂O
• UV absorption: λ: 260 nm A_max: 0.400; λ: 280 nm A_max: 0.050
• storage temp.: 2-8°C
• SMILES string: O[C@@H](CS)[C@H](O)CS
• InChI: 1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+
• InChI key: VHJLVAABSRFDPM-ZXZARUISSA-N

Description

Application

Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.

Other Notes

Cleavage of disulfide bonds in proteins;[1][2] Prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis.[3]

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H412
• pcodes: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves