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B4531

Biotin disulfide N-hydroxysuccinimide ester

>98%, powder

Synonym(s):

(2-[Biotinamido]ethylamido)-3,3′-dithiodipropionic acid N-hydroxysuccinimide ester

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10 MG

$428.00

100 MG

$2,240.00

$428.00

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About This Item

Empirical Formula (Hill Notation):
C22H33N5O7S3
CAS Number:
142439-92-7
Molecular Weight:
575.72
NACRES:
NA.46
PubChem Substance ID:
24891785
UNSPSC Code:
12352203
MDL number:
MFCD00466919

Key Documents

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Product Name

Biotin disulfide N-hydroxysuccinimide ester, >98%, powder

InChI

1S/C22H33N5O7S3/c28-16(4-2-1-3-15-21-14(13-35-15)25-22(33)26-21)23-9-10-24-17(29)7-11-36-37-12-8-20(32)34-27-18(30)5-6-19(27)31/h14-15,21H,1-13H2,(H,23,28)(H,24,29)(H2,25,26,33)/t14-,15-,21-/m0/s1

SMILES string

[H][C@]12CS[C@@H](CCCCC(=O)NCCNC(=O)CCSSCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2

InChI key

LWPHUVGDBNUVHA-GXZWQRSESA-N

assay

>98%

form

powder

solubility

DMF: 50 mg/mL

storage temp.

−20°C

Quality Level

200

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This Item
B2643D128406693014
Biotin disulfide N-hydroxysuccinimide ester >98%, powder

Sigma-Aldrich

B4531

Biotin disulfide N-hydroxysuccinimide ester

Biotinamidohexanoic acid N-hydroxysuccinimide ester ≥98% (TLC), powder

Sigma-Aldrich

B2643

Biotinamidohexanoic acid N-hydroxysuccinimide ester

Didodecyl 3,3′-thiodipropionate >97%

Sigma-Aldrich

D128406

Didodecyl 3,3′-thiodipropionate

(S)-H8-BINAP technical grade

Sigma-Aldrich

693014

(S)-H8-BINAP

assay

>98%

assay

≥98% (TLC)

assay

>97%

assay

-

solubility

DMF: 50 mg/mL

solubility

H2O: ≤2 mg/mL (with sonication), DMF: 50 mg/mL (Stable up to 2 months in dry DMF.)

solubility

-

solubility

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

form

powder

form

powder

form

powder

form

powder

Application

Biotinylation reagent incorporating a spacer with a cleavable disulfide linkage. Typically coupled to primary amine in the pH range 6.5-8.5. Cleavage of disulfide requires reducing agent allowing mild recovery of biotinylated compound.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

related product

Product No.
Description
Pricing

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000304041
0000304041
SLBS8020
SLBN6008V
SLBH6028V

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M Ichikawa et al.
Bioorganic & medicinal chemistry letters, 11(13), 1769-1773 (2001-06-27)
We have prepared several mechanism-based affinity-labeling agents for possible use in isolating N-acetylglucosaminidase, in which an N-acetylglucosamine is linked to an o-monofluoro- or difluoro-methyl phenoxy glycoside with or without a cleavable disulfide group in the tether to biotin.
D Castelletti et al.
Clinical and experimental immunology, 136(2), 365-372 (2004-04-17)
Hodgkin's lymphoma patients treated with an anti-CD25 Ricin toxin A-chain (RTA)-based Immunotoxin (RFT5.dgA) develop an immune response against the toxic moiety of the immunoconjugate. The anti-RTA antibody response of 15 patients showing different clinical features and receiving different total amounts
A reagent for covalently attaching biotin to proteins via a cleavable connector arm.
C A Mouton et al.
Archives of biochemistry and biophysics, 218(1), 101-108 (1982-10-01)
Chemical probes of extended biological structures: synthesis and properties of the cleavable protein cross-linking reagent [35S]dithiobis(succinimidyl propionate).
A J Lomant et al.
Journal of molecular biology, 104(1), 243-261 (1976-06-14)

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