I0779

Interleukin-2 Soluble Receptor α human

Name: Interleukin-2 Soluble Receptor α human
Brand: SIGMA
Price: 269 USD
Availability: InStock

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

CD25, IL-2 sRα, Tac antigen

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5 μG

$269.00

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About This Item

MDL number:

MFCD01323736

UNSPSC Code:

51111800

NACRES:

NA.32

Key Documents

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biological source

human

Quality Level

200

recombinant

expressed in NSO cells

assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

0.5-1.0 mg per mL ED₅₀

mol wt

36 kDa by SDS-PAGE

packaging

pkg of 5 μg

impurities

endotoxin, tested

UniProt accession no.

P01589

storage temp.

−20°C

Gene Information

human ... IL2RA(3559)

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Show Differences

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This Item	I2406	I5403	H6291
Sigma-Aldrich I0779 Interleukin-2 Soluble Receptor α human	Sigma-Aldrich I2406 Interleukin-11 human	Sigma-Aldrich I5403 Insulin-Like Growth Factor Binding Protein-2 human	Sigma-Aldrich H6291 Interleukin-1β human
recombinant expressed in NSO cells	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in NSO cells	recombinant expressed in HEK 293 cells
assay >97% (SDS-PAGE)	assay >97% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
biological source human	biological source human	biological source human	biological source human
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
Gene Information human ... IL2RA(3559)	Gene Information human ... IL11(3589)	Gene Information human ... IGFBP2(3485)	Gene Information human ... IL1B(3553)

Biochem/physiol Actions

Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis.[1] Null mutation in IL2RA results in immune dysregulation.[2]

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

Analysis Note

The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity.

Kevin Goudy et al.

Clinical immunology (Orlando, Fla.), 146(3), 248-261 (2013-02-19)

Cell-surface CD25 expression is critical for maintaining immune function and homeostasis. As in few reported cases, CD25 deficiency manifests with severe autoimmune enteritis and viral infections. To dissect the underlying immunological mechanisms driving these symptoms, we analyzed the regulatory and

Selective growth response to IL-3 of a human leukaemic cell line with megakaryoblastic features.

G C Avanzi et al.

British journal of haematology, 69(3), 359-366 (1988-07-01)

A new human leukaemic cell line (M-O7) with the phenotypic characteristics of CFU-mega is described. Its cells are positive for T200 leucocyte common antigen (LCA) and negative with MAbs recognizing T and B cells and mature myelomonocytic antigens. In contrast

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells.

Felix J Hartmann et al.

Nature communications, 5, 5056-5056 (2014-10-04)

Genome-wide association studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T helper (TH) cell differentiation are associated with risk of developing MS. However, the underlying mechanism by which these

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