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I4375

Inosine 5′-diphosphate sodium salt

≥96%

Synonym(s):

IDP

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About This Item

Empirical Formula (Hill Notation):
C10H14N4O11P2
CAS Number:
81012-88-6
Molecular Weight:
428.19
MDL number:
MFCD00043058
UNSPSC Code:
41106305
PubChem Substance ID:
24896053
NACRES:
NA.51

Key Documents

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biological source

microbial

assay

≥96%

form

powder

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])([O-])=O)n2cnc3C(=O)NC=Nc23

InChI

1S/C10H14N4O11P2.3Na/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1

InChI key

CPIQGMJSIPVOOS-MSQVLRTGSA-K

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This Item
I4625M8386M5883
Inosine 5′-diphosphate sodium salt ≥96%

Sigma-Aldrich

I4375

Inosine 5′-diphosphate sodium salt

Inosine 5′-monophosphate disodium salt hydrate from yeast, Grade III, ≥98% (HPLC)

Sigma-Aldrich

I4625

Inosine 5′-monophosphate disodium salt hydrate

α,β-Methyleneadenosine 5′-diphosphate sodium salt CD73 inhibitor

Sigma-Aldrich

M8386

α,β-Methyleneadenosine 5′-diphosphate sodium salt

7-Methylguanosine 5′-diphosphate sodium salt ≥92.5%

Sigma-Aldrich

M5883

7-Methylguanosine 5′-diphosphate sodium salt

biological source

microbial

biological source

yeast

biological source

synthetic (organic)

biological source

synthetic (organic)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥96%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥92.5%

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

solubility

water: 50 mg/mL, clear, colorless

solubility

water: 50 mg/mL, clear to slightly hazy, colorless

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

Application

Inosine 5′-diphosphate sodium salt has been used for hystoenzymatic demonstration of nucleoside diphosphatase (NDPase).[1][2]

Preparation Note

Prepared from muscle or bacterial ADP.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H371

Hazard Classifications

STOT SE 2

target_organs

Eyes,Central nervous system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000487056
0000487055
0000487057
0000487057
0000487056

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Edwin K Jackson et al.
The Journal of pharmacology and experimental therapeutics, 321(2), 799-809 (2007-02-23)
Stimulation of adenylyl cyclase causes cellular efflux of cAMP, and cAMP (unlike adenosine) is stable in blood. Therefore, it is conceivable that cAMP could function as a circulating adenosine prohormone by local target-organ conversion of distally released cAMP to adenosine
Satoko Ohkubo et al.
European journal of pharmacology, 577(1-3), 35-43 (2007-09-20)
In C6 glioma cells, adenine nucleotides, especially AMP, and adenosine inhibited cell proliferation in time- and concentration-dependent manners. alpha,beta-methylene-ADP, an ecto-5'-nucleotidase inhibitor, suppressed the hydrolysis of AMP and reversed the inhibition of cell growth induced by AMP but not by
John A Duley et al.
Therapeutic drug monitoring, 27(5), 647-654 (2005-09-22)
Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN). However, a sense of uncertainty about the usefulness of TGNs and other
Increased number of microglia in the brain of severe combined immunodeficient (SCID) mice
Lorke DE, et al.
Histochemistry and Cell Biology, 130(4), 693-697 (2008)
CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model
Almolda B, et al.
Journal of Neuroimmunology, 209(1-2), 65-80 (2009)
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