M8278

Margatoxin

Name: Margatoxin
Brand: SIGMA
Price: 975 USD

Synonym(s):

MgTx

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About This Item

Empirical Formula (Hill Notation):

C₁₇₈H₂₈₆N₅₂O₅₀S₇

CAS Number:

145808-47-5

Molecular Weight:

4178.95

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00132225

Key Documents

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SMILES string

S1SCC2NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C3NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C8N(CCC8)C(=O)C9N(CCC9)C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C%10N(CCC%10)C(=O)C(NC(=O)C(NC(=O)C(CSSC3)NC(=O)C(

InChI

1S/C178H286N52O50S7/c1-15-91(7)140(225-172(273)141(92(8)16-2)224-169(270)138(190)96(12)233)171(272)211-114(75-134(189)240)158(259)223-139(90(5)6)170(271)208-107(43-25-31-64-184)153(254)221-125-87-287-283-83-121-161(262)206-111(58-69-281-14)157(258)210-113(74-133(188)239)147(248)194-78-136(242)199-102(38-20-26-59-179)149(250)217-120-82-282-284-84-122(220-156(257)110(54-57-132(187)238)205-150(251)106(42-24-30-63-183)207-166(267)126-44-33-66-228(126)176(277)119(81-232)216-173(274)142(97(13)234)226-165(125)266)163(264)212-115(70-89(3)4)174(275)230-68-35-47-129(230)177(278)229-67-34-46-128(229)168(269)222-124(86-286-285-85-123(219-152(253)105(204-160(120)261)41-23-29-62-182)164(265)213-116(72-99-48-50-101(235)51-49-99)175(276)227-65-32-45-127(227)167(268)214-117(178(279)280)73-100-76-191-88-195-100)162(263)203-103(39-21-27-60-180)148(249)198-95(11)145(246)202-109(53-56-131(186)237)155(256)209-112(71-98-36-18-17-19-37-98)146(247)193-79-137(243)200-108(52-55-130(185)236)154(255)215-118(80-231)159(260)197-93(9)143(244)192-77-135(241)196-94(10)144(245)201-104(151(252)218-121)40-22-28-61-181/h17-19,36-37,48-51,76,88-97,102-129,138-142,231-235H,15-16,20-35,38-47,52-75,77-87,179-184,190H2,1-14H3,(H2,185,236)(H2,186,237)(H2,187,238)(H2,188,239)(H2,189,240)(H,191,195)(H,192,244)(H,193,247)(H,194,248)(H,196,241)(H,197,260)(H,198,249)(H,199,242)(H,200,243)(H,201,245)(H,202,246)(H,203,263)(H,204,261)(H,205,251)(H,206,262)(H,207,267)(H,208,271)(H,209,256)(H,210,258)(H,211,272)(H,212,264)(H,213,265)(H,214,268)(H,215,255)(H,216,274)(H,217,250)(H,218,252)(H,219,253)(H,220,257)(H,221,254)(H,222,269)(H,223,259)(H,224,270)(H,225,273)(H,226,266)(H,279,280)

InChI key

OVJBOPBBHWOWJI-UHFFFAOYSA-N

form

powder

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CACNA1D(776)
mouse ... CACNA1D(12289)
rat ... CACNA1D(29716)

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Show Differences

1 of 4

This Item	A2202	K1514	EMU066361
Sigma-Aldrich M8278 Margatoxin	Sigma-Aldrich A2202 ω-Agatoxin TK	Sigma-Aldrich K1514 Kurtoxin	Sigma-Aldrich EMU066361 MISSION^® esiRNA
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
form powder	form powder	form solid	form lyophilized powder
Gene Information human ... CACNA1D(776) mouse ... CACNA1D(12289) rat ... CACNA1D(29716)	Gene Information human ... CACNA1A(773) mouse ... CACNA1A(12286) rat ... CACNA1A(25398)	Gene Information human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911) mouse ... CACNA1G(12291), CACNA1H(58226), CACNA1I(239556) rat ... CACNA1G(29717), CACNA1H(114862), CACNA1I(56827)	Gene Information mouse ... CACNA1A(12286), Cacna1a(12286)
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Biochem/physiol Actions

Margatoxin is an α-KTx toxin, which is majorly used in ion channel research.[1] It is a 39-amino acid peptide, which is a specific K(V)1.3 channel voltage-dependent K⁺channel blocker.[2] Margatoxin is an immunosuppressant that is isolated from the venom of the scorpion Centruroides margaritatus.[3]

Other Notes

Toxin in Centruroides margaritatus (scorpion)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Different potassium channels are involved in relaxation of rat renal artery induced by P1075.

Aleksandra Novakovic et al.

Basic & clinical pharmacology & toxicology, 111(1), 24-30 (2012-01-10)

The ATP-sensitive K(+) channels opener (K(ATP)CO), P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N″-3-pyridylguanidine], has been shown to cause relaxation of various isolated animal and human blood vessels by opening of vascular smooth muscle ATP-sensitive K(+) (K(ATP)) channels. In addition to the well-known effect on the

Voltage-dependent biphasic effects of chloroquine on delayed rectifier K(+)-channel currents in murine thymocytes.

I Kazama et al.

The journal of physiological sciences : JPS, 62(3), 267-274 (2012-02-14)

Lymphocytes are of rich in delayed rectifier K(+)-channels (Kv1.3) in their plasma membranes, and the channels play crucial roles in the lymphocyte activation and proliferation. Since chloroquine, a widely used anti-malarial drug, exerts immunosuppressive effects, it will affect the channel

Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers.

Raveendra Anangi et al.

PloS one, 7(12), e52965-e52965 (2013-01-10)

The K(v)1.3 voltage-gated potassium channel regulates membrane potential and calcium signaling in human effector memory T cells that are key mediators of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Thus, subtype-specific K(v)1.3 blockers have potential

Targeting K(V) channels rescues retinal ganglion cells in vivo directly and by reducing inflammation.

Paulo D Koeberle et al.

Channels (Austin, Tex.), 4(5), 337-346 (2010-08-12)

Retinal ganglion cell (RGC) degeneration is an important cause of visual impairment, and results in part from microglia-mediated inflammation. Numerous experimental studies have focused on identifying drug targets to rescue these neurons. We recently showed that K(V)1.1 and K(V)1.3 channels

Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanised Mouse Model of Ulcerative Colitis.

Anna-Lena Unterweger et al.

Journal of Crohn's & colitis, 15(11), 1943-1958 (2021-04-24)

The potassium channel Kv1.3 is a potentially attractive therapeutic target in T cell-mediated inflammatory diseases, as the activity of antigen-activated T cells is selectively impeded by Kv1.3 inhibition. In this study, we examined Kv1.3 as a potential therapeutic intervention point

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