R3877

Rose Bengal sodium salt

Name: Rose Bengal sodium salt
Brand: SIGMA

Dye content ≥85 %

Synonym(s):

4,5,6,7-Tetrachloro-2′,4′,5′,7′-tetraiodofluorescein sodium salt, Acid Red 94, Bengal Rose B sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂Cl₄I₄Na₂O₅

CAS Number:

632-69-9

Molecular Weight:

1017.64

Colour Index Number:

45440

Beilstein/REAXYS Number:

3645857

EC Number:

211-183-3

MDL number:

MFCD00005043

UNSPSC Code:

12171500

PubChem Substance ID:

24899365

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Key Documents

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form

powder

composition

Dye content, ≥85%

solubility

H₂O: 1 mg/mL

SMILES string

[Na+].[Na+].[O-]C(=O)c1c(Cl)c(Cl)c(Cl)c(Cl)c1C2=C3C=C(I)C(=O)C(I)=C3Oc4c(I)c([O-])c(I)cc24

InChI

1S/C20H4Cl4I4O5.2Na/c21-10-8(9(20(31)32)11(22)13(24)12(10)23)7-3-1-5(25)16(29)14(27)18(3)33-19-4(7)2-6(26)17(30)15(19)28;;/h1-2,29H,(H,31,32);;/q;2*+1/p-2

InChI key

UWBXIFCTIZXXLS-UHFFFAOYSA-L

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Exact location of sensorimotor cortex injury after photochemical modulation; evidence of stroke based on stereological and morphometric studies in mice.

Maryam Shahi et al.

Lasers in medical science, 36(1), 91-98 (2020-04-17)

The integrity of the structural cerebral cortex is disrupted after stroke either at the macroscopic or microscopic levels. Therefore, many attempts have been gathered to circumvent stroke-associated problems in the brain tissue. The current study was aimed to design an

Rescue of cortical neurovascular functions during the hyperacute phase of ischemia by peripheral sensory stimulation.

Lun-De Liao et al.

Neurobiology of disease, 75, 53-63 (2015-01-13)

To investigate the potential therapeutic effects of peripheral sensory stimulation during the hyperacute phase of stroke, the present study utilized electrophysiology and photoacoustic imaging techniques to evaluate neural and vascular responses of the rat cortex following ischemic insult. We employed

Longitudinal monitoring of mesoscopic cortical activity in a mouse model of microinfarcts reveals dissociations with behavioral and motor function.

Matilde Balbi et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 39(8), 1486-1500 (2018-03-10)

Small vessel disease is characterized by sporadic obstruction of small vessels leading to neuronal cell death. These microinfarcts often escape detection by conventional magnetic resonance imaging and are identified only upon postmortem examination. Our work explores a brain-wide microinfarct model

Gamma frequency activation of inhibitory neurons in the acute phase after stroke attenuates vascular and behavioral dysfunction.

Matilde Balbi et al.

Cell reports, 34(5), 108696-108696 (2021-02-04)

Alterations in gamma oscillations occur in several neurological disorders, and the entrainment of gamma oscillations has been recently proposed as a treatment for neurodegenerative disease. Optogenetic stimulation enhances recovery in models of stroke when applied weeks after injury; however, the

FD&C Red No. 105 (Rose Bengal B) neutralizes the thyroid tumor promoting effect of iodine-deficient diet in rats.

J Kanno et al.

Toxicology, 99(1-2), 107-113 (1995-05-05)

The effect of 3,4,5,6-tetrachloro-2',4',5',7'-tetraiodo-fluorescein sodium salt (Rose Bengal B or FD&C Red No. 105, molecular weight 1017.6) on the thyroid of rats treated with N-bis(2-hydroxypropyl)-nitrosamine (DHPN) and iodine-deficient (I-def) diet is studied. Six-week-old male F344 rats were divided into seven

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