R9525

RX 821002 hydrochloride

Name: RX 821002 hydrochloride
Brand: SIGMA

solid, ≥98% (HPLC)

Synonym(s):

2-[2-(2-Methoxy-1,4-benzodioxanyl)]imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₄N₂O₃ · HCl

CAS Number:

109544-45-8

Molecular Weight:

270.71

MDL number:

MFCD00069343

UNSPSC Code:

12352200

PubChem Substance ID:

24278684

NACRES:

NA.77

Key Documents

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assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H₂O: >20 mg/mL

SMILES string

Cl[H].COC1(COc2ccccc2O1)C3=NCCN3

InChI

1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H

InChI key

IMPOOMVZVWKSAP-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Show Differences

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This Item	I6138	E3263	A0232
Sigma-Aldrich R9525 RX 821002 hydrochloride	Sigma-Aldrich I6138 Idazoxan hydrochloride	Sigma-Aldrich E3263 Efaroxan hydrochloride	Sigma-Aldrich A0232 Alfuzosin hydrochloride
assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form -	form -	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage condition desiccated	storage condition -	storage condition -	storage condition desiccated
solubility H₂O: >20 mg/mL	solubility H₂O: 50 mg/mL	solubility H₂O: >20 mg/mL	solubility DMSO: >10 mg/mL, H₂O: insoluble
color white	color -	color -	color -

Biochem/physiol Actions

Selective α₂-adrenoceptor antagonist

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000395015

027M4717V

010M4616V

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Investigation of the distribution and function of alpha-adrenoceptors in the sheep isolated internal anal sphincter.

S J Rayment et al.

British journal of pharmacology, 160(7), 1727-1740 (2010-07-24)

We have investigated the distribution of alpha-adrenoceptors in sheep internal anal sphincter (IAS), as a model for the human tissue, and evaluated various imidazoline derivatives for potential treatment of faecal incontinence. Saturation and competition binding with (3)H-prazosin and (3)H-RX821002 were

Adrenergic mechanisms of the Kölliker-Fuse/A7 area on the control of water and sodium intake.

S Gasparini et al.

Neuroscience, 164(2), 370-379 (2009-09-01)

The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intake in rats treated with furosemide (FURO) combined with captopril (CAP). In the present

Selective enhancement of mesocortical dopaminergic transmission by noradrenergic drugs: therapeutic opportunities in schizophrenia.

Mercè Masana et al.

The international journal of neuropsychopharmacology, 14(1), 53-68 (2010-08-13)

The superior efficacy of atypical vs. classical antipsychotic drugs to treat negative symptoms and cognitive deficits in schizophrenia appears related to their ability to enhance mesocortical dopamine (DA) function. Given that noradrenergic (NE) transmission contributes to cortical DA output, we

Modulation of inflammatory response via alpha2-adrenoceptor blockade in acute murine colitis.

A Bai et al.

Clinical and experimental immunology, 156(2), 353-362 (2009-03-03)

Inflammatory bowel disease (IBD) is characterized by heavy production of proinflammatory cytokines such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta. Interactions of the autonomic nervous system with local immune cells play an important role in the development of IBD

Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task.

Yia-Ping Liu et al.

Journal of biomedical science, 16, 72-72 (2009-08-15)

The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) were administered with RBX (0, 3.0 and 10 mg/kg) in the

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