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SML0148

Imidapril hydrochloride

≥98% (HPLC)

Synonym(s):

(4S)-3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid hydrochloride, Novaloc, TA 6366, Tanapril

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About This Item

Empirical Formula (Hill Notation):
C20H27N3O6 · HCl
CAS Number:
89396-94-1
Molecular Weight:
441.91
MDL number:
MFCD00923828
UNSPSC Code:
12352200
PubChem Substance ID:
329825196
NACRES:
NA.77

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assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -50 to -70° in ethanol (c=0.5)

color

white to tan

solubility

H2O: ≥5 mg/mL

originator

Trinity Pharma Solutions

storage temp.

−20°C

SMILES string

Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2[C@@H](CN(C)C2=O)C(O)=O

InChI

1S/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1

InChI key

LSLQGMMMRMDXHN-GEUPQXMHSA-N

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This Item
Q0632B0935R0404
Imidapril hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0148

Imidapril hydrochloride

Quinapril hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

Q0632

Quinapril hydrochloride

Benazepril hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

B0935

Benazepril hydrochloride

Ramipril ≥98% (HPLC)

Sigma-Aldrich

R0404

Ramipril

form

powder

form

solid

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: ≥5 mg/mL

solubility

H2O: >10 mg/mL

solubility

H2O: >5 mg/mL

solubility

DMSO: ~18 mg/mL

color

white to tan

color

white

color

-

color

white

General description

Imidapril comprises large acyl moiety and is hydrolyzed by carboxylesterase (CES) 1.[1]

Application

Imidapril hydrochloride may be used to test its effect on pharyngeal and laryngeal muscle to treat impaired swallowing.[2]
Imidapril hydrochloride was used as a standard in bioequivalence test by LC/MS method.[3]

Biochem/physiol Actions

Angiotensin Converting Enzyme (ACE) inhibitor
Imidapril hydrochloride is a long-acting inhibitor of angiotensin converting enzyme used in the treatment of hypertension, congestive heart failure and diabetic nephropathy.[4] It restores decreased airway sensation and bladder sensation in patients with multiple sclerosis.[4][5]
Imidapril is a potent angiotensin converting enzyme inhibitor and anti-hypertensive.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Trinity Pharma Solutions. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000426115
0000426115
0000220802
0000220802
0000183127

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Takashi Moriya et al.
European journal of pharmacology, 861, 172601-172601 (2019-08-20)
Pharmacological agents that elevate dopamine and substance P concentrations have been suggested to prevent aspiration pneumonia and improve impaired swallowing processes. However, little is known about the effects of such agents on swallowing activities induced in motor nerves innervating the
Imidapril, an angiotensin-converting enzyme inhibitor, can reverse loss of bladder sensation.
R Sakakibara et al.
Journal of neurology, neurosurgery, and psychiatry, 77(9), 1100-1101 (2006-08-18)
Roberto Fogari et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 34(12), 1321-1326 (2011-08-05)
To evaluate the relationship between plasma plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) changes during treatment with imidapril and candesartan in hypertensive patients with metabolic syndrome. A total of 84 hypertensive patients with metabolic syndrome were randomized to
Mitsuru Ohishi et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 33(11), 1150-1154 (2010-08-13)
The principal means for reducing proteinuria in patients with chronic kidney disease are strong blockade of the renin-angiotensin system and strict regulation of blood pressure (BP). This study compared the efficacy of the maximum permissible doses of two common angiotensin
Tetsuya Matsumoto et al.
Hypertension (Dallas, Tex. : 1979), 56(3), 364-368 (2010-07-08)
The renin-angiotensin system regulates the vascular fibrinolytic balance. In the human forearm vasculature, angiotensin-converting enzyme (ACE) inhibitors (ACE-Is) increase the release of t-PA through endogenous bradykinin. We tested the hypothesis that ACE inhibition and sex modulate the endogenous coronary release
View All Related Papers

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