T8657

Sigma-Aldrich

Trichloroacetic acid

suitable for electrophoresis, suitable for fixing solution (for IEF and PAGE gels), ≥99%

Synonym(s):
TCA
Linear Formula:
Cl3CCOOH
CAS Number:
Molecular Weight:
163.39
Beilstein/REAXYS Number:
970119
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NB.22

Quality Level

vapor density

<1 (vs air)

vapor pressure

1 mmHg ( 51 °C)

assay

≥99%

form

powder or flakes

application(s)

cell analysis: suitable
electrophoresis: suitable

turbidity

≤3 NTU (1 g/ml)

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

water: 1 g/mL, clear, colorless

density

1.62 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.001%
nitrate (NO3-): ≤0.002%
phosphate (PO43-): ≤5 ppm
sulfate (SO42-): ≤0.02%

cation traces

Fe: ≤0.0005%
heavy metals (as Pb): ≤0.002%

suitability

suitable for fixing solution (for IEF and PAGE gels)

storage temp.

2-8°C

SMILES string

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

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General description

Trichloroacetic acid (TCA) is produced during the chlorination of water comprising natural organic material. It is a novel reagent used in clinical laboratories for deproteinization of body fluids. In addition, TCA is also used in the treatment of genital warts and acne scars.

Application

Trichloroacetic acid has been used:
  • for hydrolysis of DNA isolated from the cell
  • for precipitation of glutathione isolated from seminal plasma
  • as a fixative in microscopy

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Packaging

250, 500 g in glass bottle
1 kg in glass bottle

Signal Word

Danger

Hazard Statements

hazcat

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3

Target Organs

Respiratory system

storage_class_code

8B - Non-combustible, corrosive hazardous materials

WGK Germany

WGK 2

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

> 113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Cryotherapy compared with trichloroacetic acid in treating genital warts.
Godley MJ
Sexually Transmitted Infections, 63(6), 390-392 (1987)
Determination of total protein in spinal fluid with sulphosalicylic acid and trichloroacetic acid
Meulemans O
Clinica Chimica Acta; International Journal of Clinical Chemistry, 5(5), 757-761 (1960)
Quantitation of DNA fragmentation with diphenylamine
Boraschi D and Maurizi G
Apoptosis-a laboratory manual of experimental methods, 153-161 (1998)
Teratogenic activity of trichloroacetic acid in the rat
Smith MK, et al.
Teratology, 40(5), 445-451 (1989)
Atmospheric pressure pulsed plasma induces cell death in photosynthetic organs via intracellularly generated ROS
Seol Y, et al.
Scientific reports, 7(1), 589-589 (2017)

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