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  • Acetylcholinesterase inhibition within the lycorine series of Amaryllidaceae alkaloids.

Acetylcholinesterase inhibition within the lycorine series of Amaryllidaceae alkaloids.

Natural product communications (2012-08-23)
Jerald J Nair, Johannes van Staden
ABSTRACT

The plant family Amaryllidaceae occupies a privileged status within the botanical hierarchy due to its horticultural and ornamental appeal, as well as its widespread usage in the traditional medicinal practices of indigenous peoples across the globe. Of greater significance are the unique, structurally-diverse alkaloid constituents produced by members of the family, which has spawned several biologically significant molecules. In this regard, the Alzheimer's drug galanthamine has gained much prominence due to its selective and reversible inhibitory interaction with the enzyme acetylcholinesterase (AChE), of significance in the progression of neurodegeneration associated with Alzheimer's disease (AD). The lycorine series of compounds within the family have recently emerged as novel inhibitors of AChE, in some instances with higher levels of activity compared with the commercial drug galanthamine, making them attractive targets for natural product and synthetically-driven structure-activity relationship studies. This brief survey traces the emergence of lycorine compounds over the past decade as promising leads in the therapeutic approach towards AD and their possible future advancement onto the clinical stage.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Lycorine hydrochloride, ≥98% (TLC), powder