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  • Differences in antiproliferative effect of STAT3 inhibition in HCC cells with versus without HBV expression.

Differences in antiproliferative effect of STAT3 inhibition in HCC cells with versus without HBV expression.

Biochemical and biophysical research communications (2015-04-23)
Yun Hong, Lin Zhou, Haiyang Xie, Weilin Wang, Shusen Zheng
ABSTRACT

Chronic infection with hepatitis B virus (HBV) plays an important role in the etiology of hepatocellular carcinoma (HCC). Signal transducer and activator of transcription 3 (STAT3) inactivation could inhibit the tumor growth of HCC. In this study, differential antiproliferative effect of STAT3 inhibition was observed with HBV-related HCC cells being more resistant than non-HBV-related HCC cells. Resistance of HBV-related HCC cells to STAT3 inhibition was positively correlated to the expression of HBV. Enhanced ERK activation after STAT3 blockade was detected in HBV-related HCC cells but not in non-HBV-related HCC cells. Combined ERK and STAT3 inhibition eliminates the discrepancy between the two types of HCC cells. Moderate reduced HBV expression was found after STAT3 inhibition. These findings disclose a discrepancy in cellular response to STAT3 inhibition between non-HBV-related and HBV-related HCC cells and underscore the complexity of antiproliferative effect of STAT3 inactivation in HBV-related HCC cells.

MATERIALS
Product Number
Brand
Product Description

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