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11412272001

Roche

Transforming Growth Factor-β1, human (hTGF-β1)

recombinant (CHO cells)

Synonym(s):

hTGF

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1 mL

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$706.00

About This Item

UNSPSC Code:
12352207
NACRES:
NA.54
Biological source:
human
Recombinant:
expressed in CHO cells
Assay:
>95% (SDS-PAGE)
Form:
solution
Mol wt:
25,000 Da
Impurities:
<0.1 EU/μgtested (LAL test)

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biological source

human

recombinant

expressed in CHO cells

assay

>95% (SDS-PAGE)

form

solution

potency

<0.1 ng/mL EC50

mol wt

25,000 Da

packaging

pkg of 1 mL (1 μg)

manufacturer/tradename

Roche

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.1 EU/μgtested (LAL test)

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... TGFB1(7040)

General description

Recombinant, human TGF- β1 is produced in CHO (Chinese Hamster Ovary) cells and purified by standard chromatographic techniques.
Solution in PBS and 1 mg/ml BSA, filtered through 0.2 μm pore size membrane.

Application

Transforming growth factor-β1, human (hTGF-β1) has been used to explore function and underlying mechanism of periostin (PN) during orthodontic periodontal ligament remodeling.

Biochem/physiol Actions

Species specificity: Transforming growth factor-β1 (TGF-β1) is effective on human and mouse cells.
Specific activity/EC50: <0.1 ng/ml, at least the same specific activity (EC<SUB>50) compared to the indicated standard is guaranteed.
Transforming Growth Factor-β1, human (hTGF-β1), is a multifunctional growth factor affecting many functions in a variety of different cells.
Transforming growth factor-β (TGF-β) family comprises of a group of multifunctional cytokines which are involved in controlling apoptosis, growth and differentiation of cells, and play important role during embryo development.

Preparation Note

Working concentration: 0.01 - 10 ng/ml
Recombinant, human TGF-β 1 exerts its biological activity in the concentration range of 0.01–10 ng/ml.
Working solution: Dilute the concentrated TGF-β1 solution (1 μg/ml) with PBS or culture medium containing BSA [or HSA (human serum albumin)], 1 mg/ml (0.1%) or serum 1–10%.
Storage conditions (working solution): For best results, prepare appropriate aliquots and store at -15 to -25 °C.
Note: Avoid repeated freezing and thawing.

Analysis Note

Purity: >95% (SDS-PAGE)
Endotoxin level: <0.1 EU/μg (LAL-test), <10 EU/ml (LAL-test)
(Note: 1 EU corresponds to 0.1 ng)

Other Notes

Chain Length 2 x 112 AA
EC50 definition: The concentration of hTGF-β1 that is required to mediate half maximal inhibition of DNA synthesis (BrdU incorporation) with Mv1-Lu cells.
For life science research only. Not for use in diagnostic procedures.
Two identical polypeptide chains (112 amino acids) connected by disulfide bridges, identical to natural hTGF-β1.

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Sigma-Aldrich

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Sigma-Aldrich

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Transforming Growth Factor-α human

description

recombinant (CHO cells)

description

TGF-β1, Xeno-free, recombinant, expressed in HEK 293 cells, suitable for cell culture

description

≥97% (SDS-PAGE), recombinant, expressed in Sf21 cells, lyophilized powder, suitable for cell culture

description

TGF-α, recombinant, expressed in E. coli, powder, suitable for cell culture

recombinant

expressed in CHO cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in Sf21 cells

recombinant

expressed in E. coli

biological source

human

biological source

human

biological source

human

biological source

human

assay

>95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥97% (SDS-PAGE)

assay

≥98% (SDS-PAGE and HPLC)

form

solution

form

lyophilized powder

form

lyophilized powder

form

powder

mol wt

25,000 Da

mol wt

dimer 25 kDa (non-glycosylated)

mol wt

protein 70 kDa

mol wt

5.5 kDa

UniProt accession no.

P01137

UniProt accession no.

P01137

UniProt accession no.

P01137

UniProt accession no.

P01135

Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

does not flash

Flash Point (°C)

does not flash

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