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186562

Tetrahydrofuran

≥99.9%, anhydrous, contains 250 ppm BHT as inhibitor

1 of 2 reviewers took part in a promotion

Synonym(s):

THF, Butylene oxide, Oxolane, Tetramethylene oxide

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Size/SKUAvailabilityPrice
100 mL

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$84.60
1 L

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$171.00
2 L

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$245.00
4 x 2 L

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$742.00
12 x 100 mL

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$809.00
6 x 1 L

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$822.00
18 L

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$1,390.00

About This Item

Linear Formula:
(CH2)3CH2O
CAS Number:
Molecular Weight:
72.11
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12191501
EC Number:
203-726-8
MDL number:
Beilstein/REAXYS Number:
102391
Assay:
≥99.9%
Grade:
anhydrous
Bp:
65-67 °C (lit.)
Vapor pressure:
114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

$84.60


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Product Name

Tetrahydrofuran, anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

grade

anhydrous

Quality Segment

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

610 °F

contains

250 ppm BHT as inhibitor

expl. lim.

1.8-11.8 %

impurities

≤0.005% peroxides (as H2O2), <0.002% water (All units except 100 mL), <0.005% water (100 mL pkg)

refractive index

n20/D 1.407 (lit.)

pH

~7

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

solubility

H2O: soluble

density

0.889 g/mL at 25 °C (lit.)

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

General description

Our anhydrous solvents deliver exceptionally low water content, making them the ideal choice for moisture-sensitive laboratory applications. Packaged in the exclusive Sure/Seal™ septum bottle system, they are reliably protected against moisture ingress from first use to last drop. The innovative Sure/Seal™ closurecombines an advanced plug-style liner with an airtight elastomer and crimp capdesign to ensure consistent product integrity. Three unique liner materialsprovide optimal chemical compatibility across a broad range of solvents. Sure/Seal™ packaging is proven to maintain anhydrous conditions even after repeated punctures. With more than 70 products across all major solvent families, available in pack sizes from 100 mL to 2 L, the portfolio meets virtually every laboratory need. By choosing ready-to-use anhydrous solvents in Sure/Seal™ packaging, researchers eliminate the need for time-consuming and hazardous in-house solvent drying and distillation - saving time, reducing risk, and improving reproducibility.

Application

Anhydrous solvents in Sure/Seal™ packaging are essential wherever water contaminationwould compromise experimental results. They are widely used in moisture-sensitive applications such as organic synthesis - including Grignard reactions, organometallic chemistry, and catalysis - as well as in peptide,oligonucleotide, and pharmaceutical synthesis.

Other Notes

Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (414247) and Cyclopentyl methyl ether (675970)

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

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Show Differences

1 of 1

This Item
401757439215
description

anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

description

anhydrous, ≥99.9%, inhibitor-free

description

suitable for HPLC, ≥99.9%, inhibitor-free

grade

anhydrous

grade

anhydrous

grade

HPLC grade

assay

≥99.9%

assay

≥99.9%

assay

≥99.9%

Quality Level

200

Quality Level

200

Quality Level

100

solubility

H2O: soluble

solubility

H2O: soluble

solubility

H2O: soluble

form

liquid

form

liquid

form

liquid

pH

~7

pH

~7

pH

-


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Signal Word

Danger

Target Organs

Central nervous system, Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

Flash Point (°F)

-6.2 °F - closed cup

Flash Point (°C)

-21.2 °C - closed cup

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3



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Questions

1–10 of 10 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is it necessary to use a coupling for the Pure pac 2?

    1 answer
    1. Yes, the Pure pac 2 requires a coupling.

      Helpful?

  4. Can you recommend a Solvent Extractor for organics from aqueous solution?

    1 answer
    1. Solvent extractors are often used for the quantitative extraction of organics from aqueous solutions and separations in immunoassays. The MIXXOR system has been applied successfully in many laboratory solvent extraction operations and is ideal for the rapid screening of alternative solvents for specific extraction problems.

      Helpful?

  5. What are some of the preservatives used in the most common ethers and chlorinated solvents and why are they added?

    1 answer
    1. Certain solvents will degrade over time requiring special handling and storage considerations. In addition, the products of certain degradation processes pose a potential safety risk if present at sufficiently high levels. For these types of materials, small amounts of stabilizing chemicals are added to slow down or stop material degradation.

      Helpful?

  6. Who do I contact about larger solvent volume needs?

    1 answer
    1. Email us at labessentials@sial.com or visit Sigma-Aldrich Fine Chemicals for development and manufacturing-scale inquiries: safcglobal@sial.com

      Helpful?

  7. What are the options for drying solvents?

    1 answer
    1. Sigma-Aldrich offers a full range of high-purity solvents with extremely low water levels specifically manufactured for moisture sensitive Organic and Biotech applications.  Sigma-Aldrich also carries various drying agents such as molecular sieves, which are typically compatible with organic solvents.

      Helpful?

  8. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  9. What apparatus do you recommend for HPLC solvent filtration?

    1 answer
    1. The Sigma-Aldrich Vacuum Filtration Assembly gives you all the components you need including: funnel top, fritted glass funnel support, filtration flask, aluminum clamp, and silicone stopper.  The Acrodisc Syringe Filters offer high quality filtration for analytical samples, certified for HPLC to ensure low extractable and available in a broad range of membranes to meet sample compatibility requirements.

      Helpful?

  10. Why do peroxides form in certain solvents and how do I test for it?

    1 answer
    1. A significant number of laboratory solvents can undergo autoxidation under normal storage conditions to form unstable and potentially dangerous peroxide by-products. Molecular structure is the primary factor relating to a material’s potential for hazardous peroxide formation.  It is important to understand the stability of materials in use and if unclear, consult Sigma-Aldrich Technical Support, techserv@sial.com

      Helpful?

Reviews

1 of 2 reviewers took part in a promotion

Active Filters

  1. Cambridge
    • Reviews 7
    • Votes 18
    5 out of 5 stars.

    THF

    Very good quality THF. Reactions done with this solvent went well.

    Helpful?

  2. 1 Ratings-Only Review