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72309

Nicotinic acid

≥99.5% (HPLC)

Synonym(s):

3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

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100 g
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$55.80
500 g
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$119.00

About This Item

Linear Formula:
NC5H4CO2H
CAS Number:
Molecular Weight:
123.11
UNSPSC Code:
12352209
NACRES:
NA.26
PubChem Substance ID:
EC Number:
200-441-0
Beilstein/REAXYS Number:
109591
MDL number:

$55.80


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biological source

synthetic

Quality Segment

assay

≥99.5% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.2% water

ign. residue

≤0.05%

color

colorless to white

mp

234-238 °C, 236-239 °C (lit.)

solubility

water: 0.1 g/10 mL, clear, colorless

density

1.473 g/cm3 at 25 °C

SMILES string

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

General description

Nicotinic acid, also referred as Niacin or vitamin B3, is a water soluble vitamin. It is present in vitamin-enriched bread, liver, meat, fish, poultry, potatoes, green vegetables, peanuts and cereals.

Application

Nicotinic acid has been used as a standard in NAD+ precursor rescue experiments. It has also been used as a vitamin supplement in various culture media such as complete medium (CM) and synthetic medium.

Biochem/physiol Actions

Nicotinic acid or Niacin regulates lipid metabolism by reducing low density lipoprotein (LDL), increasing high-density lipoprotein (HDL) and by inhibiting the progression of atherosclerosis and coronary artery lesions. Niacin deficiency leads to pellagra. In addition to vitamin supplement, niacin is also used as a broad spectrum lipid drug.

Other Notes

Coenzyme and Cofactors, vol 2: Pyridine Nucleotide Coenzymes

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This Item
N4126N5410N0761
description

≥99.5% (HPLC)

description

≥98%

description

meets USP testing specifications

description

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | mammalian: suitable, cell culture | plant: suitable, cell culture | insect: suitable

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

assay

≥99.5% (HPLC)

assay

≥98%

assay

99.0-101.0% dry basis

assay

≥98%

form

powder

form

powder

form

powder

form

powder

solubility

water: 0.1 g/10 mL, clear, colorless

solubility

-

solubility

-

solubility

1 M NaOH: soluble 50 mg/mL, clear, colorless to very faintly yellow

color

colorless to white

color

white to off-white

color

white

color

white to off-white


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

379.4 °F - closed cup

flash_point_c

193 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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