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A2181

Acetyl coenzyme A lithium salt

≥93% (HPLC)

Synonym(s):

Acetyl-CoA, Acetyl-S-CoA Li3

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1 mg

Available to ship TODAYfromMILWAUKEE

$71.40
5 mg

Estimated to ship onApril 30, 2026fromMILWAUKEE

$114.00
10 mg

Estimated to ship onMay 19, 2026fromMILWAUKEE

$178.00
25 mg

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$399.00
100 mg

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$1,160.00

About This Item

Empirical Formula (Hill Notation):
C23H38N7O17P3S · xLi+
CAS Number:
32140-51-5
Molecular Weight:
809.57 (free acid basis)
NACRES:
NA.51
PubChem Substance ID:
24890633
UNSPSC Code:
41106305
MDL number:
MFCD00167406
Form:
powder
Assay:
≥93% (HPLC)
Solubility:
H2O: soluble 100 mg/mL, clear, colorless

$71.40

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Quality Level

300

assay

≥93% (HPLC)

form

powder

solubility

H2O: soluble 100 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23

InChI

1S/C23H38N7O17P3S.3Li/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;;;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);;;/q;3*+1/p-3/t13-,16-,17-,18+,22-;;;/m1.../s1

InChI key

FTRFBNATWBKIQU-JHJDYNLLSA-K

Gene Information

human ... CHAT(1103), HAT1(8520), KAT2A(2648), KAT2B(8850), KAT5(10524)
mouse ... HAT1(107435), KAT2A(14534), KAT2B(18519), KAT5(81601)
rat ... HAT1(296501), KAT2A(303539), KAT2B(301164), KAT5(192218)

General description

This moisture-sensitive powder should be stored desiccated at −20°C.

Application

Acetyl coenzyme A is suitable in CAT reporter assay for the measurement of chloramphenicol acetyltransferase by incubating the cell extract with 0.1 μCi [14C] chloramphenicol and 0.5mM acetyl-CoA.[1][2][3][4]
An essential cofactor in enzymatic acetyl transfer reactions.

Biochem/physiol Actions

Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.
Alterations in the gene encoding acetyl-CoA have been linked to Alzheimer′s disease and mild cognitive impairment.[5] Defects in the gene cause myasthenic syndrome associated with episodic apnea. [6][7]

Preparation Note

Acetyl CoA is soluble in deionized water at 100 mg/mL. Acetyl CoA is stable in neutral and moderately acidic solutions but will hydrolyze in alkaline and strongly acidic solutions. Aqueous solutions stored in single-use aliquots are stable for up to two weeks at −20°C and up to 6 months at −80°C.
Prepared enzymatically

Other Notes

For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource.

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This Item
A2056C3019C2643
Acetyl coenzyme A lithium salt ≥93% (HPLC)

Sigma-Aldrich

A2181

Acetyl coenzyme A lithium salt

Acetyl coenzyme A trisodium salt ≥93% (HPLC), powder

Sigma-Aldrich

A2056

Acetyl coenzyme A trisodium salt

Coenzyme A trilithium salt ≥93%

Sigma-Aldrich

C3019

Coenzyme A trilithium salt

Coenzyme A, oxidized lithium salt ≥85%

Sigma-Aldrich

C2643

Coenzyme A, oxidized lithium salt

solubility

H2O: soluble 100 mg/mL, clear, colorless

solubility

H2O: 100 mg/mL

solubility

-

solubility

-

assay

≥93% (HPLC)

assay

≥93% (HPLC)

assay

≥93%

assay

≥85%

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

form

powder

form

powder

form

powder

form

solid

Gene Information

human ... CHAT(1103), HAT1(8520), KAT2A(2648), KAT2B(8850), KAT5(10524)
mouse ... HAT1(107435), KAT2A(14534), KAT2B(18519), KAT5(81601)
rat ... HAT1(296501), KAT2A(303539), KAT2B(301164), KAT5(192218)

Gene Information

human ... CHAT(1103), HAT1(8520), KAT2A(2648), KAT2B(8850), KAT5(10524)
mouse ... HAT1(107435), KAT2A(14534), KAT2B(18519), KAT5(81601)
rat ... HAT1(296501), KAT2A(303539), KAT2B(301164), KAT5(192218)

Gene Information

-

Gene Information

-

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000534483
0000534483
0000499688
0000499688
0000499678

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Devis Sinani et al.
Journal of virology, 85(23), 12124-12133 (2011-09-23)
Bovine herpesvirus 1 (BHV-1) infection induces clinical symptoms in the upper respiratory tract, inhibits immune responses, and can result in life-threatening secondary bacterial infections. Following acute infection, BHV-1 establishes latency in sensory neurons within trigeminal ganglia. Periodically, reactivation from latency
Juliette Adjo Aka et al.
Handbook of experimental pharmacology, 206, 1-12 (2011-09-01)
Lysine (K) acetylation refers to transfer of the acetyl moiety from acetyl-CoA to the ε-amino group of a lysine residue. This is posttranslational and reversible, with its level dynamically maintained by lysine acetyltransferases (KATs) and deacetylases (KDACs). Traditionally, eukaryotic KDACs
Prabhjot Singh et al.
Protein and peptide letters, 18(5), 507-517 (2011-01-18)
The distinct biochemical function of endoplasmic reticulum (ER) protein Calreticulin (CR) catalyzing the transfer of acyl group from acyloxycoumarin to a receptor protein was termed calreticulin transacylase (CRTAase). The present study, unlike the previous reports of others utilizing CR-deficient cells
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Global Trade Item Number

SKUGTIN
A2181-25MG04061833349731
A2181-100MG04061833349717
A2181-5MG04061833349762
A2181-10MG04061835551163
A2181-1MG04061833349724

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