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B8041

Biglycan from bovine articular cartilage

essentially salt-free, lyophilized powder

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0.5 mg
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$1,270.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.75
MDL number:
MFCD00676525
Form:
essentially salt-free, lyophilized powder
Biological source:
bovine articular cartilage
Mol wt:
200-350 kDa

$1,270.00

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biological source

bovine articular cartilage

Quality Segment

200

form

essentially salt-free, lyophilized powder

mol wt

200-350 kDa

packaging

glass bottle of 0.5 mg

technique(s)

cell culture | mammalian: suitable

solubility

water: soluble ≥2.00 mg/mL, clear, colorless

UniProt accession no.

P21809

shipped in

dry ice

storage temp.

−20°C

Gene Information

cow ... BGN(280733)

General description

proteoglycan consisting of a 45 kDa core protein and two chrondroitin/dermatan sulfate glycosaminoglycan chains

Biochem/physiol Actions

Biglycan interacts with collagen type I and II, fibronectin and TGF-β. In a low ionic strength (less than 3 mM phosphate) buffer, Biglycan binds more strongly to collagen type I. At higher ionic strengths, Biglycan will instead increase the inhibition effect of TGF-β on osteoclast proliferation at a concentration of 4-20 mg/mL. It also functions to prevent the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg/mL. As an extracellular component, Biglycan binds TGF-β 1, facilitates bone mineralization and supports osteoblast differentiation thru BMP-4 binding.

Preparation Note

This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 μm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.

Other Notes

Biglycan is a 200-350 kDa proteoglycan consisting of a 45 kDa core protein and two chondroitin/dermatan sulfate glycosaminoglycan chains.

Disclaimer

Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.

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Biglycan from bovine articular cartilage essentially salt-free, lyophilized powder

Sigma-Aldrich

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Ubiquitin from bovine erythrocytes BioUltra, ≥98% (SDS-PAGE), essentially salt-free, lyophilized powder

Sigma-Aldrich

U6253

Ubiquitin from bovine erythrocytes

description

essentially salt-free, lyophilized powder

description

lyophilized powder

description

salt-free, lyophilized powder

description

BioUltra, ≥98% (SDS-PAGE), essentially salt-free, lyophilized powder

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

western blot: suitable

biological source

bovine articular cartilage

biological source

bovine articular cartilage

biological source

bovine articular cartilage

biological source

bovine erythrocytes

mol wt

200-350 kDa

mol wt

-

mol wt

~100 kDa

mol wt

-

form

essentially salt-free, lyophilized powder

form

lyophilized powder

form

salt-free, lyophilized powder

form

essentially salt-free, lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Gene Information

cow ... BGN(280733)

Gene Information

cow ... AGC1(280985)

Gene Information

cow ... DCN(280760)

Gene Information

bovine ... LOC(101902760)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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