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C2436

Cytochrome c from Saccharomyces cerevisiae

≥85% based on Mol. Wt. 12,588 basis

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25 mg
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$347.00
100 mg
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$1,100.00

About This Item

CAS Number:
9007-43-6
UNSPSC Code:
12352202
EC Number:
232-700-9
NACRES:
NA.61
MDL number:
MFCD00130890
Form:
powder
Assay:
≥85% based on Mol. Wt. 12,588 basis
Biological source:
Saccharomyces cerevisiae
Mol wt:
12,588 Da

$347.00

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biological source

Saccharomyces cerevisiae

Quality Segment

assay

≥85% based on Mol. Wt. 12,588 basis

form

powder

mol wt

12,588 Da

technique(s)

cell based assay: suitable

solubility

water: 10 mg/mL, clear, red to red-brown (dark red)

UniProt accession no.

application(s)

cell analysis

storage temp.

−20°C

Gene Information

Saccharomyces cerevisiae ... CYC1(853507)

General description

Cytochrome c (Cytc) comprises 104 amino acids and is a nuclear-encoded mitochondrial protein. This peripheral membrane protein is in spherical shape and has a molecular weight of 12,000 Da.

Application

Cytochrome c from Saccharomyces cerevisiae has been used in oocyte injection to induce caspase-3 activation and p38 MAPK (mitogen-activated protein kinase). It has also been used to analyze the aerobic reactions of nitric oxide.

Biochem/physiol Actions

The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen.
The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen. Tracking cellular localization of cytochrome c in S. cerervisiae demonstrates that mitochondria are strongly involved in programmed cell death, a process very similar to apoptosis in higher organisms.
Cytochrome c (Cytc) participates in mitochondrial electron transport and intrinsic type II apoptosis. It plays a key role in aerobic energy production. This multi-functional enzyme serves as a single electron carrier. Cytc helps in the formation of the apoptosome.

Preparation Note

Prepared without using TCA.

Analysis Note

Care has been taken to maintain the native form of the protein. It has not been artificially oxidized or reduced during purification. Contains variable amounts of reduced cytochrome c.

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

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Cytochrome c from Saccharomyces cerevisiae ≥85% based on Mol. Wt. 12,588 basis

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Sigma-Aldrich

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Sigma-Aldrich

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Alcohol Dehydrogenase from Saccharomyces cerevisiae

description

≥85% based on Mol. Wt. 12,588 basis

description

Type II

description

for inducing inflamatory response

description

-

assay

≥85% based on Mol. Wt. 12,588 basis

assay

-

assay

-

assay

-

technique(s)

cell based assay: suitable

technique(s)

-

technique(s)

flow cytometry: suitable, tissue culture: suitable

technique(s)

-

biological source

Saccharomyces cerevisiae

biological source

Saccharomyces cerevisiae

biological source

Saccharomyces cerevisiae

biological source

Saccharomyces cerevisiae

mol wt

12,588 Da

mol wt

-

mol wt

-

mol wt

~150,000

form

powder

form

powder or solid

form

powder with small lumps

form

powder

UniProt accession no.

P00044

UniProt accession no.

-

UniProt accession no.

-

UniProt accession no.

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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