The purification procedure of this product is based on literature references for chymotrypsin A. Therefore, it is believed to be Chymotrypsin A (or Alpha-Chymotrypsin). However, the product is not specifically tested for chymotrypsin B, C, or CTRL, so the presence of B, C, or CTRL cannot be ruled out.
C8946
α-Chymotrypsin from human pancreas
lyophilized powder
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| Size/SKU | Availability | Price |
|---|---|---|
1 vial | Available to ship TODAYfromMILWAUKEE | $787.00 |
About This Item
CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-671-2
MDL number:
EC Number:
eCl@ss:
42010112
Biological source:
human pancreas
$787.00
Available to ship TODAYDetails
biological source
human pancreas
Quality Segment
form
lyophilized powder
mol wt
25 kDa
packaging
vial of ≥10 BTEE units
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CTRB1(1504)
General description
α-Chymotrypsin belongs to the trypsin family of serine proteases. It is secreted as an inactive precursor chymotrypsinogen to the intestine. The cleavage of peptide bond at amino acid 148 forms α-chymotrypsin. Chymotrypsinogen is encoded by the gene CTRB1 and is mapped to 16q23.1 in the human chromosome.
Application
Human α-chymotrypsin has been used in a study to assess the quantitative structure-activity relationships for organophosphates binding to trypsin and chymotrypsin. Human α-chymotrypsin has also been used in a study to investigate the direct detection of native proteins in biological matrices using extractive electrospray ionization mass spectrometry.
α-Chymotrypsin from human pancreas has been used to test inhibition by N-alkyl isatins against mammalian serine proteases.
Biochem/physiol Actions
A serine protease that hydrolyzes peptide bonds with aromatic or large hydrophobic side chains (Tyr, Trp, Phe, Met) on the carboxyl end of the bond.
Analysis Note
Protein determined by A1%/280
Other Notes
One unit will hydrolyze 1.0 μmole of BTEE per min at pH 7.8 at 25°C.
1 of 1
This Item | |||
|---|---|---|---|
| description lyophilized powder | description (TLCK treated to inactivate residual tryspin activity), Type VII, essentially salt-free, lyophilized powder, ≥40 units/mg protein | description Type I-S, essentially salt-free, lyophilized powder | description Type II, lyophilized powder, ≥40 units/mg protein |
| Gene Information human ... CTRB1(1504) | Gene Information cow ... CTRB1(618826) | Gene Information cow ... CTRB1(618826) | Gene Information cow ... CTRB1(618826) |
| biological source human pancreas | biological source - | biological source - | biological source - |
| form lyophilized powder | form essentially salt-free, lyophilized powder | form essentially salt-free, lyophilized powder | form lyophilized powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| mol wt 25 kDa | mol wt 25 kDa | mol wt 25 kDa | mol wt 25 kDa |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 1
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Does product number C8946, which is α-Chymotrypsin from the human pancreas, contain one or both of the three types of chymotrypsin produced by the human pancreas, namely chymotrypsin B form, chymotrypsin C, and the rarer form called "CTRL"?
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