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D8428

Decorin from bovine articular cartilage

salt-free, lyophilized powder

Synonym(s):

Decorin protein

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0.5 mg
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$552.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.75
MDL number:
MFCD00283027
Form:
salt-free, lyophilized powder
Biological source:
bovine articular cartilage
Mol wt:
~100 kDa

$552.00

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biological source

bovine articular cartilage

Quality Level

200

form

salt-free, lyophilized powder

mol wt

~100 kDa

packaging

glass bottle of 0.5 mg

technique(s)

cell culture | mammalian: suitable

solubility

PBS: ≥2.00 mg/mL, clear, colorless to yellow

UniProt accession no.

P21793

storage temp.

−20°C

Gene Information

cow ... DCN(280760)

General description

Decoran is a small proteoglycan composed of a chondroitin/dermatan sulfate glycosaminoglycans attached to a 40 kDa core protein. It is found primarily in the extracellular matrix of articular cartilage. Decorin interacts with collagen types I and II via its core protein wherein it delays fibrillogenesis. Decorin also interacts with fibronectin, thrombospondin and TGF-β isoforms, and the EGF-receptor.
Decorin from bovine articular cartilage is a proteoglycan that belongs to the small leucine-rich repeat proteoglycans and proteins (SLRPs) family. Decorin is present in almost all tissues. It has a protein core composed of leucine-rich repeats (LRRs), flanked by two cysteine-rich regions.

Application

Decorin from bovine articular cartilage has been used in solid phase binding assay (ELISA), binding assays, binding inhibition assay, parasite binding assays, scaffold fabrication, quartz crystal microbalance assay, inhibition of CSA (chondroitin sulphate A) binding assay and glycans and glycan biotinylation.

Biochem/physiol Actions

Decorin plays an important role in guiding the proper assembly of collagen during fibrillogenesis. Deficiency in decorin results in altered tissue structure and function. It controls growth factors like EGF and TGF-β. Decorin blocks aggregation of fibrils into fibers and fibrillogenesis in cell-free constructs of polymerized type I collagen.

Other Notes

Decorin is an approx. 100 kDa proteoglycan consisting of a 40 kDa core protein and one chondroitin or dermatan sulfate glycosaminoglycan chain. From 0.2 μm filtered solution prior to lyophilization.

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This Item
B8041C9301F1141
Decorin from bovine articular cartilage salt-free, lyophilized powder

Sigma-Aldrich

D8428

Decorin from bovine articular cartilage

Biglycan from bovine articular cartilage essentially salt-free, lyophilized powder

Sigma-Aldrich

B8041

Biglycan from bovine articular cartilage

Collagen from chicken sternal cartilage Type II (Miller), powder, BioReagent, suitable for cell culture

Sigma-Aldrich

C9301

Collagen from chicken sternal cartilage

Fibronectin bovine plasma solution, sterile-filtered, BioReagent, suitable for cell culture

Sigma-Aldrich

F1141

Fibronectin bovine plasma

biological source

bovine articular cartilage

biological source

bovine articular cartilage

biological source

chicken (Sternal cartilage)

biological source

bovine plasma

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

form

salt-free, lyophilized powder

form

essentially salt-free, lyophilized powder

form

powder

form

solution

mol wt

~100 kDa

mol wt

200-350 kDa

mol wt

-

mol wt

-

Gene Information

cow ... DCN(280760)

Gene Information

cow ... BGN(280733)

Gene Information

chicken ... COL2A1(395069)

Gene Information

bovine ... FN1(280794)

UniProt accession no.

P21793

UniProt accession no.

P21809

UniProt accession no.

P02460

UniProt accession no.

P07589

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000517236
0000517236
0000335441
0000335441
0000209565

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Related Content

Seda Duran G Ler et al.
Indian journal of ophthalmology, 69(2), 369-373 (2021-01-20)
The aims of this study were to evaluate the effects of decorin (DCN) in rat oxygen-induced retinopathy (OIR) model and to compare the results with those of bevacizumab. Twenty-eight newborn Sprague-Dawley rats were randomly divided into four groups. Group I
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
Clausen T M, et al.
The Journal of Biological Chemistry, 287(28), 23332-23345 (2012)
Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels.
Reese S P, et al.
Matrix Biology, 32(7-8), 414-423 (2013)
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Global Trade Item Number

SKUGTIN
D8428-.5MG04061833589625

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