F3133

Fibroblast Growth Factor from bovine pituitary

Name: Fibroblast Growth Factor from bovine pituitary
Brand: SIGMA
Price: 9220 CZK

lyophilized, suitable for cell culture

Synonym(s):

FGF

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10 μG

CZK 9,220.00

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About This Item

CAS Number:

62031-54-3

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00166724

Biological source:

bovine pituitary glands

Form:

lyophilized powder

Mol wt:

16.4 kDa

Impurities:

endotoxin, tested

Key Documents

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Product Name

Fibroblast Growth Factor from bovine pituitary, suitable for cell culture

biological source

bovine pituitary glands

Quality Level

200

form

lyophilized powder

potency

1-100 ng/mL

mol wt

16.4 kDa

packaging

pkg of 10 and 5X10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

storage temp.

−20°C

Related Categories

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Growth Factors and Cytokines

Molecular Biology & Functional Genomics

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Show Differences

1 of 4

This Item	F5542	F1168	F7301
Sigma-Aldrich F3133 Fibroblast Growth Factor from bovine pituitary	Sigma-Aldrich F5542 Fibroblast Growth Factor-Acidic human	Sigma-Aldrich F1168 Fibroblast Growth Factor-9 human	Sigma-Aldrich F7301 Fibroblast Growth Factor-18 human
biological source bovine pituitary glands	biological source human	biological source human	biological source human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
mol wt 16.4 kDa	mol wt 15.5 kDa	mol wt ~25 kDa	mol wt predicted mol wt 21.2 kDa
storage condition avoid repeated freeze/thaw cycles	storage condition avoid repeated freeze/thaw cycles	storage condition avoid repeated freeze/thaw cycles	storage condition avoid repeated freeze/thaw cycles

General description

Fibroblast growth factors (FGF) are glycoproteins concealed in the extracellular matrix and cell surface. There are around 22 different types of FGFs known. These factors weigh in the range of 17 to 34kDa and they possess a conserved sequence of 120 amino acids.

Application

A natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.

Fibroblast Growth Factor from bovine pituitary has been used in in vitro testicular cell culture. It has also been used as a component of myogenic culture medium.

Biochem/physiol Actions

Fibroblast growth factors (FGF) actively participate in cellular responses including embryogenesis and organogenesis. It specifically controls cell proliferation, differentiation and migration. FGF is known to regulate nervous system functions, tissue repair mechanism and wound healing. It also controls angiogenesis of tumor cells. Abnormal FGF mediated signaling induces tumor angiogenesis, by stimulating cancer cell proliferation and survival. FGFs carries out its function by mediating through four receptor tyrosine kinases : FGF-receptors FGFR1, FGFR2, FGFR3 and FGFR4.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.1 mg/ml BSA.

Preparation Note

Purified glands by a modification of the method of Gospodarowicz.

Analysis Note

Although the major mitogenic component of this product is FGF2, the activity per unit weight of protein is less than that of purified FGF2.

The biological activity is measured using a 3-day MTT assay.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Modulation of osteogenic, adipogenic and myogenic differentiation of mesenchymal stem cells by submicron grooved topography

Wang PY, et al.

Journal of Materials Science. Materials in Medicine, 23(12), 3015-3028 (2012)

Characterization and In Vitro Differentiation of Korean Ring-Necked Pheasant (Phasianus colchicus) Male Germ Cells

Jeong DK, et al.

Journal of Embryology transfer , 29(4), 351-359 (2014)

Cellular signaling by fibroblast growth factor receptors

Eswarakumar VP, et al.

Cytokine & Growth Factor Reviews, 16(2), 139-149 (2005)

Fibroblast growth factor signalling: from development to cancer

Turner N and Grose R

Nature Reviews. Cancer, 10(2), 116-116 (2010)

A testis-mediated germline chimera production based on transfer of chicken testicular cells directly into heterologous testes

Lee YM, et al.

Biology of Reproduction, 75(3), 380-386 (2006)

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Global Trade Item Number

SKU	GTIN
F3133-10UG	04061833613528
F3133-5X10UG	04061833613535

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