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F7301

Fibroblast Growth Factor-18 human

>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):

FGF-18

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25 μg

Estimated to ship onMay 06, 2026fromMILWAUKEE

$710.00

About This Item

UNSPSC Code:
12352202
EC Number:
201-064-4
NACRES:
NA.32
MDL number:
MFCD01867042

$710.00

Estimated to ship onMay 06, 2026Details

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biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

≤0.5 ng/mL

mol wt

predicted mol wt 21.2 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

O76093

storage temp.

−20°C

Gene Information

human ... FGF18(8817)

General description

FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of.[1] This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.[2]

Biochem/physiol Actions

FGF-18 is a heparin binding growth factor, which stimulates the proliferation and activation of cells that express the FGF receptors.
FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same.[1] It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage.[3] In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.[2]
Stimulates the proliferation and activation of cells that express the FGF receptors.

Physical form

Lyophilized from a 0.2 μm filtered solution in 10 mM Tris, pH 8.0 + 20mM NaCl.

Analysis Note

The biological activity is determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.

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Fibroblast Growth Factor-18 human >95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

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Fibroblast Growth Factor-4 human FGF-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

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Fibroblast Growth Factor-4 human

Fibroblast Growth Factor-Basic from bovine pituitary FGF-Basic, suitable for cell culture

Sigma-Aldrich

F5392

Fibroblast Growth Factor-Basic from bovine pituitary

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

-

biological source

human

biological source

human

biological source

human

biological source

bovine pituitary glands

assay

>95% (SDS-PAGE and HPLC)

assay

≥97% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

~90% (SDS-PAGE and N-terminal analysis)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

impurities

endotoxin, tested

impurities

≤1.0 EU/mg (LAL test)

impurities

<1 EU/μg (LAL test)

impurities

<0.5 EU/vial

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000269790
SLCR4693
0000269790
SLCR4828
SLCF6119

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Articles

Fibroblast Growth Factor Family (FGF)

Fibroblast growth factors in cell culture and various growth factors for your research

Related Content

Data Sheet - F7301

Instructions

The crystal structure of fibroblast growth factor 18 (FGF18).
Alan Brown et al.
Protein & cell, 5(5), 343-347 (2014-03-29)
Yoshifumi Mori et al.
The Journal of biological chemistry, 289(14), 10192-10200 (2014-03-01)
To identify genes that maintain the homeostasis of adult articular cartilage and regenerate its lesions, we initially compared four types of chondrocytes: articular (AA) versus growth plate (AG) cartilage chondrocytes in adult rats, and superficial layer (IS) versus deep layer
Wei Wei et al.
The Journal of clinical investigation, 123(10), 4435-4448 (2013-09-11)
High-throughput genomic technologies have identified biomarkers and potential therapeutic targets for ovarian cancer. Comprehensive functional validation studies of the biological and clinical implications of these biomarkers are needed to advance them toward clinical use. Amplification of chromosomal region 5q31-5q35.3 has
View All Related Papers

Global Trade Item Number

SKUGTIN
F7301-25UG04061833619469

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