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F7301

Fibroblast Growth Factor-18 human

Name: Fibroblast Growth Factor-18 human
Brand: SIGMA
Price: 710 USD

>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder

Sinónimos:

FGF-18

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A ustedes/SKU	Disponibilidad	Precio
25 μg	Comprobar disponibilidad del carrito	$710.00

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UNSPSC Code:

12352202

EC Number:

201-064-4

NACRES:

NA.32

MDL number:

MFCD01867042

$710.00

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Propiedades

biological source

human

Quality Segment

200

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE and HPLC)

form

lyophilized powder

potency

≤0.5 ng/mL

mol wt

predicted mol wt 21.2 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

O76093

storage temp.

−20°C

Gene Information

human ... FGF18(8817)

Descripción

General description

FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of.[1] This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.[2]

Biochem/physiol Actions

FGF-18 is a heparin binding growth factor, which stimulates the proliferation and activation of cells that express the FGF receptors.

FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same.[1] It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage.[3] In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.[2]

Stimulates the proliferation and activation of cells that express the FGF receptors.

Physical form

Lyophilized from a 0.2 μm filtered solution in 10 mM Tris, pH 8.0 + 20mM NaCl.

Analysis Note

The biological activity is determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.

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Este artículo	F5542	F5392	F3133
Sigma-Aldrich F7301 Fibroblast Growth Factor-18 human	Sigma-Aldrich F5542 Fibroblast Growth Factor-Acidic human	Sigma-Aldrich F5392 Fibroblast Growth Factor-Basic from bovine pituitary	Sigma-Aldrich F3133 Fibroblast Growth Factor from bovine pituitary
assay >95% (SDS-PAGE and HPLC)	assay ≥97% (SDS-PAGE)	assay ~90% (SDS-PAGE and N-terminal analysis)	assay -
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant -	recombinant -
biological source human	biological source human	biological source bovine pituitary glands	biological source bovine pituitary glands
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
impurities endotoxin, tested	impurities ≤1.0 EU/mg (LAL test)	impurities <0.5 EU/vial	impurities endotoxin, tested

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c