14-920-M

CLK1, active

Name: CLK1, active
Brand: MM

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Sobre este item

Código UNSPSC:

12352200

eCl@ss:

32160405

NACRES:

NA.41

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fonte biológica

human

Nível de qualidade

100
300

peso molecular

M_w 45 kDa

fabricante/nome comercial

Upstate^®

técnica(s)

activity assay: suitable (kinase)

nº de adesão NCBI

NM_004071

nº de adesão UniProt

P49759

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Este Item	14-917-M	SRP5278	SAB2108770
Sigma-Aldrich 14-920-M CLK1, active	Sigma-Aldrich 14-917-M CLK4 Protein, active, 10 µg	Sigma-Aldrich SRP5278 CHK1, active, His tagged human	Sigma-Aldrich SAB2108770 Anti-CLK4 (N-terminal) antibody produced in rabbit HRP conjugated
biological source human	biological source human	biological source human	biological source rabbit
technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) -	technique(s) -
UniProt accession no. P49759	UniProt accession no. Q9HAZ1	UniProt accession no. -	UniProt accession no. -
mol wt M_w 45 kDa	mol wt M_w 46 kDa	mol wt ~59 kDa	mol wt 57 kDa
Quality Level 100, 300	Quality Level 100, 300	Quality Level -	Quality Level -
NCBI accession no. NM_004071	NCBI accession no. NM_020666	NCBI accession no. NM_001274	NCBI accession no. NM_020666

Descrição geral

CLK1 is a dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.

Product Source: N-terminal 6His-tagged, recombinant, human CLK1, amino acids 130-end expressed by baculovirus in Sf21 insect cells

Ações bioquímicas/fisiológicas

Target Sub-Family: CMGC

Embalagem

Also available in 250μg size as catalog # 14-920M and in bulk as catalog # 14-920-K.

forma física

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol

Purified using immobilized metal affinity chromatography.

Nota de preparo

6 months at -70°C

Nota de análise

Routinely evaluated by phosphorylation of peptide ERMRPRKRQGSVRRRV

Outras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictogramas

GHS07

Palavra indicadora

Warning

Frases de perigo

H317

Declarações de precaução

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Classificações de perigo

Skin Sens. 1

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)