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Merck

91228

Trichloressigsäure

BioUltra, ≥99.5% (T)

Synonym(e):

TCA

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Lineare Formel:
Cl3CCOOH
CAS-Nummer:
Molekulargewicht:
163.39
UNSPSC Code:
12352101
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-927-2
Beilstein/REAXYS Number:
970119
MDL number:

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Produktname

Trichloressigsäure, BioUltra, ≥99.5% (T)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

SMILES string

OC(=O)C(Cl)(Cl)Cl

grade

biotech. grade

vapor density

<1 (vs air)

vapor pressure

1 mmHg ( 51 °C)

product line

BioUltra

assay

≥99.5% (T)

form

crystals
flakes

impurities

insoluble matter, passes filter test

ign. residue

≤0.05%

refractive index

n20/D 1.62 (lit.)

pH

<1.0 (25 °C, 0.5 M in H2O)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

1.62 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤30 mg/kg
nitrate (NO3-): ≤20 mg/kg
phosphate (PO43-): ≤10 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.5 M in H2O

UV absorption

λ: 260 nm Amax: 1.60
λ: 280 nm Amax: 0.15

Quality Level

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Dieser Artikel
T9159T865791230
assay

≥99.5% (T)

assay

≥99.0%

assay

≥99%

assay

≥99.5% (T)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

crystals, flakes

form

-

form

powder or flakes (or crystals)

form

flakes

pH

<1.0 (25 °C, 0.5 M in H2O)

pH

-

pH

-

pH

-

solubility

H2O: 0.5 M at 20 °C, clear, colorless

solubility

H2O: 0.5 M at 20 °C, clear, colorless

solubility

water: 1 g/mL, clear, colorless

solubility

water: soluble 81.7 g/L at 20 °C

bp

196 °C (lit.)

bp

196 °C (lit.)

bp

196 °C (lit.)

bp

196 °C (lit.)

Application

Traditionell zur Fällung von Proteinen verwendet. Zur Bestimmung der Proteinkonzentration durch quantitative Fällung. Zum Entkalken und als Fixationsmittel in der Mikroskopie verwendet.
Trichloroacetic acid (TCA) has been used:
  • to determine its effect on avian embryos during an exposure window encompassing cardiac specification[1]
  • as a cell fixative[2][3][4]
  • to terminate the O-acetylserine (thiol)lyase (OASTL) enzymatic assay[4]
  • for the precipitation of acidic ribosomal proteins (RPs)[5]

General description

Trichloroacetic acid (TCA) is derived from Trichloroethylene (TCE) metabolism.[6] It is used as an acid decalcifying agent. TCA is used as a fixative for nuclear staining and protein precipitation.[7]

Other Notes

Concentration of protein by quantitative precipitation; Cytochemical demonstration of DNA with a thiazine dye.

pictograms

CorrosionEnvironment

signalword

Danger

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A

Lagerklasse

8B - Non-combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

>235.4 °F - closed cup

flash_point_c

> 113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Analysenzertifikate (COA)

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Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Extraction and Activity of O-acetylserine (thiol) lyase (OASTL) from Microalga Chlorella sorokiniana
Salbitani G and Carfagna S
Bio-protocol (2016)
CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain
Thomas L, et al.
Cancer & Metabolism, 7(1), 2-2 (2019)
Efficacy of 5-FU or oxaliplatin monotherapy over combination therapy in colorectal cancer
Toloudi M, et al.
Journal of Cancer Therapy, 6(04), 345-345 (2015)
M.K. Dutt
Science and Culture, 51, 196-196 (1985)
Cardiogenic effects of trichloroethylene and trichloroacetic acid following exposure during heart specification of avian development
Drake V, et al.
Toxicological Sciences, 94(1), 153-162 (2006)

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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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