G2295

Glimepirid

≥98% (HPLC), insulin secretagogue, solid

• Empirische Formel (Hill-System): C₂₄H₃₄N₄O₅S
• CAS-Nummer: 93479-97-1
• Molekulargewicht: 490.62
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895093
• NACRES: NA.77
• MDL number: MFCD00878417

Eigenschaften

• Produktname: Glimepirid, ≥98% (HPLC), solid
• SMILES string: CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O
• InChI: 1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-
• InChI key: WIGIZIANZCJQQY-RUCARUNLSA-N
• assay: ≥98% (HPLC)
• form: solid
• color: white
• mp: 212.2-214.5 °C
• solubility: DMSO: >10 mg/mL
• originator: Sanofi Aventis
• storage temp.: room temp
• Quality Level: 100
• Gene Information: human ... ABCC8(6833), KCNJ1(3758), KCNJ11(3767)

Beschreibung

Application

Glimepirid wird derzeit zur Behandlung von Typ-2-Diabetes eingesetzt.

Glimepiride has been used:

• as a hypoglycemic drug to test its anti-diabetic functionality in human umbilical vein cells (HUVECs)[1]
• as a sulfonylurea ATP-sensitive potassium channel (K_ATP) channel inhibitor in breast cancer MDA-MB-231 cells[2]
• in glucose-stimulated insulin secretion (GSIS) assays of neonatal islet-like cell clusters (NICCs) to test its effect on insulin secretion[3]

Biochem/physiol Actions

Glimepirid ist ein wirksamer Blocker kardialer K_ATP-Kanäle, aktiviert durch Pinacidil mit einem IC₅₀ von 6,8 nM.

Wirksamer Blocker kardialer K_ATP-Kanäle.

Glimepiride reduces blood glucose levels by stimulating the pancreatic β cells to secrete insulin hormone. It interacts with a 65-kD protein associated with β cells.[4]

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Glimepiride is a class II biopharmaceutical[4] second-generation sulfonylurea.[5]

Sicherheitshinweise

• pictograms: GHS08
• signalword: Warning
• hcodes: H361
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)