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Merck

PRKCG

protein kinase C, gamma

Sinonimi:
PKC-gamma, PKCC, PKCG, SCA14
Specie:
ID UniProtKB:
ID gene:
  • Human(5582) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
  • Mouse(18752) protein kinase C, gamma
  • Rat(24681) protein kinase C, gamma
  • cow(282002) protein kinase C, gamma
  • Horse(100062549) protein kinase C, gamma
  • sheep(101116423) protein kinase C, gamma
  • naked mole-rat(101698346) protein kinase C, gamma
  • Domestic Rabbit(100009102) protein kinase C, gamma
  • domestic cat(101082196) protein kinase C, gamma
  • dog(484316) protein kinase C, gamma
  • domestic guinea pig(100733947) protein kinase C, gamma
  • Zebrafish(100003514) protein kinase C, gamma

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numero di prodotto
Descrizione
Specie
Acido oleico, ≥99% (GC),
Specie
human

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-PRKCG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-PRKCG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
Anti-PKCγ Antibody, clone 2B9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, rat
Applicazione
affinity binding assay
immunofluorescence

immunohistochemistry

western blot
Anti-p-PKCγ (Thr514) Antibody, clone 4F20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
inhibition assay

western blot
Anti PKC alpha + beta + gamma Antibody, clone 24GB885, Rabbit Monoclonal, clone 24GB885, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reattività con
human, rat
Applicazione
flow cytometry
immunofluorescence

western blot

Small Molecule - Inhibitor

Numero di prodotto
Descrizione
Specie
H-7 dihydrochloride, ≥98% (HPLC),
Specie
human
Tamoxifen citrate salt, ≥99%,
Specie
human
Acido oleico, ≥99% (GC),
Specie
human
UCN-01, ≥97% (HPLC), powder,
Specie
human
GSK690693, ≥98% (HPLC),
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human PRKCG,
Specie
human