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Merck

PHR1008

Acide ascorbique

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Acide L-ascorbique, Acide L-thréoascorbique, Facteur anti-scorbut, Vitamine C

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2 G

103,00 €

10 G

626,00 €

103,00 €


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A propos de cet article

Formule empirique (notation de Hill) :
C6H8O6
Numéro CAS:
Poids moléculaire :
176.12
NACRES:
NA.24
E Number:
E300
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-066-2
MDL number:
Beilstein/REAXYS Number:
84272

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Nom du produit

Acide ascorbique, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. A1300000
traceable to USP 1043003

API family

ascorbic acid

form

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

190-194 °C (dec.)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

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Cet article
1043003BP46157803
Acide ascorbique British Pharmacopoeia (BP) Reference Standard

BP461

Acide ascorbique

application(s)

food and beverages

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

food and beverages

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

form

solid

form

-

form

solid

form

solid

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, TraceCERT®

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Ascorbic Acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using hydrophilic interaction chromatography.[1]

Biochem/physiol Actions

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ascorbic acid is a powerful antioxidant and is widely used in pharmaceutical formulations.[1][2] It has proven to have a beneficial effect on age-related diseases such as cancer, atherosclerosis, ocular, neurodegenerative diseases, etc. It is mainly involved in the formation and maintenance of collagen.[3] The prolonged deficiency of ascorbic acid in diet may result in scurvy.[2]

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2886 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Method development and validation for optimised separation of salicylic, acetyl salicylic and ascorbic acid in pharmaceutical formulations by hydrophilic interaction chromatography and response surface methodology
Hatambeygi N, et al.
Journal of Chromatography A, 1218(35), 5995-6003 (2011)
L-ascorbic acid determination in pharmaceutical formulations using a biosensor based on carbon paste modified with crude extract of Zucchini (Cucurbita pepo)
Fatibello-Filho and Vieira CI
Journal of the Brazilian Chemical Society, 11(4), 412-418 (2000)
Simultaneous differential pulse voltammetric determination of ascorbic acid and caffeine in pharmaceutical formulations using a boron?doped diamond electrode
Lourencao CB, et al.
Electroanalysis, 22(15), 1717-1723 (2010)
Stefanie B Murer et al.
The Journal of nutrition, 144(2), 193-201 (2013-12-20)
Oxidative stress and low-grade systemic inflammation may contribute to the pathogenesis of obesity-induced comorbidities, including nonalcoholic fatty liver disease. Increasing intake of dietary antioxidants might be beneficial, but there are few data in obese children. To examine the effect of
Josué Kunjom Mfopou et al.
Stem cell research, 12(1), 166-177 (2013-11-19)
Definitive endoderm (DE) differentiation from mouse embryonic stem cell (mESC) monolayer cultures has been limited by poor cell survival or low efficiency. Recently, a combination of TGFβ and Wnt activation with BMP inhibition improved DE induction in embryoid bodies cultured

Articles

Simultaneous analysis of ascorbic acid and dehydroascorbic acid in various food samples by High Performance Thin Layer Chromatography (HPTLC).

A new RP-HPLC method is proposed for the determination of organic acids in 100% aqueous mobile phase using an Ascentis® Express AQ-C18 column

Questions

1–2 sur 2 questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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