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Merck

K1751

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

Ketoprofen

Synonyme(s) :

2-(3-Benzoylphenyl)propionic acid

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A propos de cet article

Formule empirique (notation de Hill) :
C16H14O3
Numéro CAS:
22071-15-4
Poids moléculaire :
254.28
NACRES:
NA.77
PubChem Substance ID:
57654315
UNSPSC Code:
12352200
EC Number:
244-759-8
MDL number:
MFCD00055790

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Nom du produit

Ketoprofen, ≥98% (TLC)

InChI key

DKYWVDODHFEZIM-UHFFFAOYSA-N

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

SMILES string

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

biological source

synthetic

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to yellow

originator

Bayer

Quality Level

200

Gene Information

human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)

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Cet article
K201234016PHR1375
Ketoprofen ≥98% (TLC)

Sigma-Aldrich

K1751

Ketoprofen

Ketoprofen meets USP testing specifications

Sigma-Aldrich

K2012

Ketoprofen

Ketoprofen VETRANAL®, analytical standard

Supelco

34016

Ketoprofen

Ketoprofen Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1375

Ketoprofen

assay

≥98% (TLC)

assay

-

assay

-

assay

-

form

powder

form

solid

form

-

form

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

300

solubility

ethanol: 50 mg/mL, clear, colorless to yellow

solubility

-

solubility

-

solubility

-

originator

Bayer

originator

-

originator

-

originator

-

biological source

synthetic

biological source

-

biological source

-

biological source

-

Application

Ketoprofen has been used:
  • as sample to analyse the effects of long storage period by chromatographic and microscopic techniques[1]
  • as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation[2]
  • in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin[3]

Biochem/physiol Actions

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis.[4] It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.[5]
Non-steroidal anti-inflammatory compound that is selective for COX-1.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Ketoprofen belongs to the class of 2-arylpropionic acid.[4]

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
WXBF2607V
BCCK2800
BCCJ8530
BCCH4038
BCCD0399

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ekaterina Blinova et al.
Biomolecules, 11(6) (2021-07-03)
The main goal of our study was to explore the wound-healing property of a novel cerium-containing N-acethyl-6-aminohexanoate acid compound and determine key molecular targets of the compound mode of action in diabetic animals. Cerium N-acetyl-6-aminohexanoate (laboratory name LHT-8-17) as a
Polyamidoamine dendrimers used as solubility enhancers of ketoprofen
Yiyun C, et al.
European Journal of Medicinal Chemistry, 40(12), 1390-1393 (2005)
In vitro chiral conversion, phase separation, and wave propagation in aged profen solutions
Sajewicz M, et al.
Journal of Liquid Chromatography and Related Technologies, 32(9), 1359-1372 (2009)
Ekaterina Blinova et al.
International journal of molecular sciences, 22(18) (2021-09-29)
The possible involvement of p53 signaling, FGFR3 expression, and FGFR3 mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 expression, FGFR3
L Saso et al.
Archives of pharmacal research, 24(2), 150-158 (2001-05-08)
The activity of nonsteroidal antiinflammatory drugs (NSAIDs) in rheumatoid arthritis is not only due to the inhibition of the production of prostaglandins, which can even have beneficial immunosuppressive effects in chronic inflammatory processes. Since we speculated that these drugs could
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