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Merck

15420

Boc-Gly-OH

≥99.0% (T), for peptide synthesis

Sinonimo/i:

N-(tert-Butoxycarbonyl)glycine, Boc-glycine

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5 G

35,10 €

25 G

118,00 €

100 G

151,00 €

35,10 €


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Informazioni su questo articolo

Formula condensata:
(CH3)3COCONHCH2COOH
Numero CAS:
Peso molecolare:
175.18
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
224-864-5
MDL number:
Beilstein/REAXYS Number:
1101514

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Nome del prodotto

Boc-Gly-OH, ≥99.0% (T)

InChI key

VRPJIFMKZZEXLR-UHFFFAOYSA-N

InChI

1S/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10)

SMILES string

CC(C)(C)OC(=O)NCC(O)=O

assay

≥99.0% (T)

form

powder or crystals

reaction suitability

reaction type: Boc solid-phase peptide synthesis

ign. residue

≤0.05%

mp

86-89 °C (lit.)
86-89 °C

application(s)

peptide synthesis

Quality Level

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Questo articolo
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Boc-Gly-OH ≥99.0% (T)

Sigma-Aldrich

15420

Boc-Gly-OH

Boc-Gly-OSu ≥99.0% (T)

Sigma-Aldrich

15423

Boc-Gly-OSu

Boc-Lys-OH ≥99.0% (NT)

Sigma-Aldrich

15456

Boc-Lys-OH

Boc-Lys-OH 99%

Sigma-Aldrich

359688

Boc-Lys-OH

form

powder or crystals

form

solid

form

solid

form

solid

assay

≥99.0% (T)

assay

≥99.0% (T)

assay

≥99.0% (NT)

assay

99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

mp

86-89 °C (lit.)

mp

165-167 °C

mp

~205 °C (dec.) (lit.)

mp

~205 °C (dec.) (lit.)

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

ign. residue

≤0.05%

ign. residue

≤0.05%

ign. residue

-

ign. residue

-

Application

Boc-Gly-OH can be used:
  • For the esterification reaction to synthesize N-Boc amino acid esters for peptide chemistry.[1]
  • For the synthesis of tripeptide H-Gly-Pro-Glu-OH, analogs of neuroprotective drugs.[2]
  • As a promoter for the allylation of hydrazones and isatin.[3]

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificati d'analisi (COA)

Lot/Batch Number

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.
De Diego SAA, et al.
Bioorganic & Medicinal Chemistry Letters, 15(9), 2279-2283 (2005)
Ceric ammonium nitrate (CAN) mediated esterification of N-Boc amino acids allows either retention or removal of the N-Boc group.
Kuttan A, et al.
Tetrahedron Letters, 45(12), 2663-2665 (2004)
Wen-Ren Li et al.
The Journal of organic chemistry, 67(14), 4702-4706 (2002-07-06)
A new approach to a CD45 protein tyrosine phosphatase inhibitor, pulchellalactam, is described. The key step of the sequence involves addition and elimination of an enolic lactam in a single step and 70% yield, employing an organocuprate reagent. The resulting
N-Boc-glycine-assisted indium-mediated allylation reaction: a sustainable approach.
Vemula SR, et al.
Tetrahedron Letters, 56(23), 3322-3325 (2015)
L Varga et al.
Hepato-gastroenterology, 27(2), 146-149 (1980-04-01)
The catabolism of the 14C-labelled pentagastrin was investigated in rats. The following results were found: -- the labelled BOC-glycine fragment is split off the pentagastrin in the small intestine -- it is absorbed through the intestinal wall, and -- enters

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Utile?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

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