PHR1540

Letrozole

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: Letrozole, 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
• Formula empirica (notazione di Hill): C₁₇H₁₁N₅
• Numero CAS: 112809-51-5
• Peso molecolare: 285.30
• NACRES: NA.24
• PubChem Substance ID: 329823451
• UNSPSC Code: 41116107
• MDL number: MFCD00866241

Proprietà

• Nome del prodotto: Letrozole, Pharmaceutical Secondary Standard; Certified Reference Material
• format: neat
• InChI: 1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
• SMILES string: N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
• InChI key: HPJKCIUCZWXJDR-UHFFFAOYSA-N
• grade: certified reference material; pharmaceutical secondary standard
• agency: traceable to Ph. Eur. Y0000685; traceable to USP 1356971
• API family: letrozole
• CofA: current certificate can be downloaded
• packaging: pkg of 1 g
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• storage temp.: 2-30°C
• Quality Level: 300
• Gene Information: human ... CYP19A1(1588)

Descrizione

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Letrozole may be used as a pharmaceutical reference standard for the determination of the analyte in biological/environmental samples[1][2] and pharmaceutical formulations[3] by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Letrozole is a non-steroidal aromatase inhibitor.

Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Letrozole is used for the treatment of breast cancer in hormone-dependent postmenopausal patients. The drug works by blocking the synthesis of estrogen, a causative agent for cancer.[1]

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA4186 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informazioni sulla sicurezza

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2 - STOT RE 2
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable