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Merck

F7876

葉酸

≥97%

別名:

PteGlu, ビタミンM, プテロイル-L-グルタミン酸

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サイズを選択してください

1 G

¥5,780

10 G

¥15,500

25 G

¥29,400

100 G

¥101,000

¥5,780


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この商品について

実験式(ヒル表記法):
C19H19N7O6
CAS番号:
分子量:
441.40
NACRES:
NA.79
PubChem Substance ID:
eCl@ss:
34058014
UNSPSC Code:
12352106
EC Number:
200-419-0
MDL number:
Beilstein/REAXYS Number:
100781

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製品名

葉酸, ≥97%

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

biological source

synthetic (organic)

assay

≥97%

form

powder

technique(s)

HPLC: suitable

color

faint orange to dark orange-yellow
faint yellow to dark yellow

mp

>285 °C

storage temp.

room temp

Quality Level

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当該品目
1286005PHR1035F0300000
葉酸 ≥97%

Sigma-Aldrich

F7876

葉酸

葉酸 United States Pharmacopeia (USP) Reference Standard

USP

1286005

葉酸

葉酸 Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1035

葉酸

葉酸 European Pharmacopoeia (EP) Reference Standard

F0300000

葉酸

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

assay

≥97%

assay

-

assay

-

assay

-

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

synthetic

form

powder

form

-

form

-

form

solid

storage temp.

room temp

storage temp.

-

storage temp.

2-30°C

storage temp.

2-8°C

color

faint orange to dark orange-yellow, faint yellow to dark yellow

color

-

color

-

color

-

Application

葉酸は、以下の目的で使用されています:
  • MCF-7乳がん細胞培養のサプリメントとしてマウスに急性腎障害を誘発する[1]
  • [2]
  • 葉酸またはTNF関連のアポトーシス含有配位子(TRAIL)抱合ナノミセルを構築する。[3]

Biochem/physiol Actions

DNAの合成、メチル化、修復に不可欠な酵素補因子。 葉酸サプリメントは、結腸直腸がんのリスクを軽減する可能性があります。
葉酸(FA)とジヒドロ葉酸(FAH2)は、それらをテトラヒドロ葉酸(THF)に還元するジヒドロ葉酸レダクターゼの基質であり、THFは「1炭素」移動をサポートします。 テトラヒドロ葉酸は、プリン、チミジル酸および様々なアミノ酸のde novo合成および翻訳後のメチル化(エピジェネティクス)に必要です。

保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


最新バージョンのいずれかを選択してください:

試験成績書(COA)

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以前この製品を購入いただいたことがある場合

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文書ライブラリにアクセスする

Surface-enhanced Raman spectroscopy of cell lysates mixed with silver nanoparticles for tumor classification.
Hassoun M, et al.
Beilstein Journal of Nanotechnology, 8, 1183-1183 (2017)
Romain Froquet et al.
Nature protocols, 4(1), 25-30 (2009-01-10)
Dictyostelium amoebae have been used as a host model to measure virulence of a wide range of bacterial pathogens. The simple protocol described here takes advantage of the ability of Dictyostelium to grow and form plaques on a lawn of
Novel water-borne polyurethane nanomicelles for cancer chemotherapy: higher efficiency of folate receptors than TRAIL receptors in a Cancerous Balb/C Mouse Model.
Ajorlou E, et al.
Pharmaceutical Research, 33(6), 1426-1439 (2016)
Fibroblast Growth Factor 23 Expression is increased in Multiple Organs in Mice with Folic Acid-induced Acute Kidney Injury.
Egli-Spichtig D, et al.
Frontiers in Physiology, 9, 1494-1494 (2018)
Silvia Ferrè et al.
Kidney international, 96(6), 1359-1373 (2019-10-12)
Sepsis is a systemic inflammatory state in response to infection, and concomitant acute kidney injury (AKI) increases mortality significantly. Endoplasmic reticulum stress is activated in many cell types upon microbial infection and modulates inflammation. The role of endoplasmic reticulum signaling

資料

Cancer research innovations address the complexity of the disease, providing advanced technologies for varied applications.

Biofiles reviews innovative technologies for cancer research, reflecting the complexity of the disease.

質問

1–2/2 質問  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      役に立ちましたか?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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