G1001

D-グルタミン酸

Name: <SC>D</SC>-グルタミン酸
Brand: SIGMA

≥99% (TLC), suitable for ligand binding assays

別名:

(R)-2-アミノグルタル酸, (R)-2-アミノペンタン二酸, D-Glu, R-(−)-1-アミノプロパン-1,3-ジカルボン酸

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この商品について

化学式:

HO₂CCH₂CH₂CH(NH₂)CO₂H

CAS番号:

6893-26-1

分子量:

147.13

NACRES:

NA.32

PubChem Substance ID:

24895031

UNSPSC Code:

12352209

EC Number:

230-000-8

MDL number:

MFCD00063112

Beilstein/REAXYS Number:

1723800

主要文書

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製品名

D-グルタミン酸, ≥99% (TLC)

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1

InChI key

WHUUTDBJXJRKMK-GSVOUGTGSA-N

SMILES string

N[C@H](CCC(O)=O)C(O)=O

assay

≥99% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

mp

200-202 °C (subl.) (lit.)

Quality Level

200

Gene Information

human ... CCR2(1231)

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当該品目	1.00291	G0355000	12-0880
Sigma-Aldrich G1001 D-グルタミン酸	Millipore 1.00291 L-Glutamic acid	G0355000 L-グルタミン酸	Sigma-Aldrich 12-0880 L-グルタミン酸
form powder	form solid	form -	form crystalline
assay ≥99% (TLC)	assay ≥99% substance (anhydrous) basis (alkalimetric)	assay -	assay ≥99.0%
technique(s) ligand binding assay: suitable	technique(s) -	technique(s) -	technique(s) -
mp 200-202 °C (subl.) (lit.)	mp 160 °C	mp 205 °C (dec.) (lit.)	mp 205 °C (dec.) (lit.)
Quality Level 200	Quality Level 100	Quality Level -	Quality Level -
color white to off-white	color -	color -	color -

Application

D-グルタミン酸は、GR（グルタミン酸ラセマーゼ）という酵素とその阻害剤の構造親和性相関（SAR）研究における使用に適しています。[1]

Biochem/physiol Actions

グルタミン酸の非天然アイソマ-

General description

D-グルタミン酸は、細菌のペプチドグリカン構造に欠かせない成分です。D-グルタミン酸を付加する酵素（murD）によりUDP-N-アセチルムラミル-L-アラニン（UDP-MurNAc-L-アラニン）へ付加されます。これは次にペプチドグリカン前駆体へと取り込まれます[2]。ペプチドグリカンは、グラム陽性菌とグラム陰性菌の細胞壁の構成成分です。グルタミン酸ラセマーゼ（GR）という酵素によるL-グルタミン酸からD-グルタミン酸への変換は、ペプチドグリカンの合成において欠かせないステップです。[1]

保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Allosteric control of an ionotropic glutamate receptor with an optical switch.

Matthew Volgraf et al.

Nature chemical biology, 2(1), 47-52 (2006-01-13)

The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across protein classes, from enzymes to motors to signaling proteins. We

Identification of the Escherichia coli murI gene, which is required for the biosynthesis of D-glutamic acid, a specific component of bacterial peptidoglycan.

P Doublet et al.

Journal of bacteriology, 174(18), 5772-5779 (1992-09-01)

The murI gene of Escherichia coli, whose inactivation results in the inability to form colonies in the absence of D-glutamic acid, was identified in the 90-min region of the chromosome. The complementation of an auxotrophic E. coli B/r strain by

Hybrid Steered Molecular Dynamics-Docking: An Efficient Solution to the Problem of Ranking Inhibitor Affinities Against a Flexible Drug Target.

Katie L Whalen et al.

Molecular informatics, 30(5), 459-471 (2011-07-09)

Existing techniques which attempt to predict the affinity of protein-ligand interactions have demonstrated a direct relationship between computational cost and prediction accuracy. We present here the first application of a hybrid ensemble docking and steered molecular dynamics scheme (with a

A descending dopamine pathway conserved from basal vertebrates to mammals.

Dimitri Ryczko et al.

Proceedings of the National Academy of Sciences of the United States of America, 113(17), E2440-E2449 (2016-04-14)

Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive

Subthalamic GAD gene therapy in a Parkinson's disease rat model.

Jia Luo et al.

Science (New York, N.Y.), 298(5592), 425-429 (2002-10-12)

The motor abnormalities of Parkinson's disease (PD) are caused by alterations in basal ganglia network activity, including disinhibition of the subthalamic nucleus (STN), and excessive activity of the major output nuclei. Using adeno-associated viral vector-mediated somatic cell gene transfer, we

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匿名

6ヶ月前

How can I determine the shelf life / expiration / retest date of this product?

1 回答
1. Technical Support
  
  6ヶ月前
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
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匿名

10ヶ月前

How is shipping temperature determined? And how is it related to the product storage temperature?

1 回答
1. Technical Support
  
  10ヶ月前
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
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