This product is tested for solubility in Methanol at 10 mg/mL. The peptide is also soluble in ethanol, butanol, DMSO, pyridine, and water (at lower rates). Long term solution stability has not been determined, when possible prepare fresh. External sources indicate stock solutions may be stored up to 6 months at -20°C in aliquots and protected from light. Please see the link below for additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/394/433/p2141pis-ms.pdf
P2141
Phalloidin Peptide
≥90% (HPLC), powder
別名:
28-(2,3-dihydroxy-2-methylpropyl)-18-hydroxy-34-(1-hydroxyethyl)-23,31-dimethyl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraene-15,21,24,26,29,32,35-heptone
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1 MG
￥50,100
￥50,100
本日発送予定詳細
高品質はそのまま、さらにお手頃な価格になりました
この商品について
実験式（ヒル表記法）:
C35H48N8O11S
CAS番号:
分子量:
788.87
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
241-484-5
MDL number:
Beilstein/REAXYS Number:
4347460
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製品名
ファロイジン from Amanita phalloides, ≥90%
InChI
1S/C35H48N8O11S/c1-15-27(47)38-22-10-20-19-7-5-6-8-21(19)41-33(20)55-13-24(34(53)43-12-18(46)9-25(43)31(51)37-15)40-32(52)26(17(3)45)42-28(48)16(2)36-30(50)23(39-29(22)49)11-35(4,54)14-44/h5-8,15-18,22-26,41,44-46,54H,9-14H2,1-4H3,(H,36,50)(H,37,51)(H,38,47)(H,39,49)(H,40,52)(H,42,48)
InChI key
KPKZJLCSROULON-UHFFFAOYSA-N
SMILES string
CC(O)C1NC(=O)C(C)NC(=O)C(CC(C)(O)CO)NC(=O)C2Cc3c(SCC(NC1=O)C(=O)N4CC(O)CC4C(=O)NC(C)C(=O)N2)[nH]c5ccccc35
biological source
Amanita phalloides
assay
≥90%
form
powder
Quality Level
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1 of 4
当該品目 | P1951 | P5282 | 50556 |
|---|---|---|---|
| assay ≥90% | assay - | assay - | assay ≥90% (HPLC) |
| biological source Amanita phalloides | biological source sequence from Amanita phalloides (synthetic: peptide sequence) | biological source sequence from Amanita phalloides (synthetic: peptide sequence) | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form powder | form solid | form solid | form - |
Application
Biochem/physiol Actions
ファロイジンは、Amanita phalloides（タマゴテングタケ）から単離された毒素であり、重合体Fアクチンに結合してそれを安定化し、
アクチンに富む構造体の機能を妨げます。
アクチンに富む構造体の機能を妨げます。
ファロイジンは、オリゴマーや単量体の形ではなく、重合体のアクチンと相互作用します。この相互作用により、解重合や分解に耐性の非常に安定化されたアクチンフィラメントになります。この毒素は、ラットで肝出血による死を誘発し、細胞は異常なアクチンのクラスター化を示します[4]。アクチンに対するファロイジンの親和性は、蛍光標識ファロイジン化合物を誘導体に変換した後、大幅には変化しません。これらの化合物は、真核細胞内のアクチンの構造と組織化の研究に使用できます。[5]
重合体のFアクチンに結合して安定化させ、アクチンリッチ構造の機能を阻害する毒素です。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
保管分類
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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How should this peptide be diluted, and with what? What are the appropriate storage conditions, and how long will it remain stable?
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